Table 2

Changes in CVD risk factors and association with percentage weight change for the Look AHEAD cohort

BaselineChange from baseline to year 1Spearman correlation of association with percentage weight loss
nMean ± SDnMean ± SDTotal cohortILI subjectsDSE subjects
Weight (kg)5,145100.71 ± 19.264,899−4.77 ± 7.57*
SBP (mmHg)5,082128.84 ± 17.174,837−4.76 ± 17.05*0.20*0.19*0.14*
DBP (mmHg)5,08270.15 ± 9.574,837−2.40 ± 8.62*0.12*0.13*0.08*
Glucose4,999153.19 ± 45.664,603−14.32 ± 46.08*0.27*0.21*0.14*
HbA1c (%)4,9997.28 ± 1.174,606−0.39 ± 1.02*0.34*0.24*0.16*
HDL cholesterol (mg/dL)4,99943.48 ± 11.834,6032.39 ± 6.97*−0.23*−0.26*−0.08*
LDL cholesterol (mg/dL)4,998112.31 ± 32.244,602−5.47 ± 28.63*−0.0040.0008−0.02
Trigylcerides (mg/dL)4,999153 (108–219)4,603−12.0 (−52 to 21)*0.26*0.31*0.16*
  • *P < 0.0001.

  • †For change in triglycerides, data are median (interquartile range). The signed-rank test was used to test whether the change from baseline to year 1 was different from 0.