Table 3 —

Metabolic characteristics and cardiovascular risk factors of subjects with normal and impaired glucose tolerance from the follow-up phase of the Sandy Lake Health and Diabetes Project (29 men; 66 women) and associations between baseline levels and changes over time in these variables*

VariableBaseline values
Change over 4-year follow-up period
A: Correlation between change in proinsulin and change in CVD variable
B: Correlation between baseline proinsulin and change in CVD variable
C: Correlation between baseline CVD variable and change in proinsulin
MeanSDMeanSDPartial rPPartial rPPartial rP
NGT/IGT/diabetes (n)41/54/054/17/24
Age at baseline (years)35.1016.97
Waist (cm)96.3511.373.165.78
C-peptide (pmol/l)831.72438.46299.25485.26
Proinsulin (pmol/l)17.0611.603.6618.40
Cholesterol (mmol/l)4.700.850.091.380.31<0.01−0.110.330.100.39
Triglycerides (mmol/l)1.610.750.292.200.250.020.030.790.230.04
LDL cholesterol (mmol/l)2.780.68−0.080.540.240.04−0.120.310.180.10
HDL cholesterol (mmol/l)1.190.260.020.200.110.32−0.030.81−0.30<0.01
ApoB (g/l)1.160.27−0.050.190.260.02−0.190.09−0.230.04
ApoAI (g/l)1.490.22−0.020.170.200.08−0.130.25−0.190.09
Systolic BP (mmHg)121.0015.484.6813.100.130.23−0.090.43−0.140.23
Diastolic BP (mmHg)68.7411.084.7411.510.110.340.070.52−0.020.83
  • *

    * Spearman correlation analysis, sample sizes vary slightly due to occasional missing values;

  • analyses adjusted for age, sex, change in C-peptide concentration, change in waist circumference, baseline and follow-up diabetes status, and baseline level of dependent and independent change variables;

  • analyses adjusted for age sex, C-peptide concentration, change in waist circumference, baseline and follow-up diabetes status, and baseline level of dependent and independent change variables.