Table 1—

Glucose counterregulatory hormone levels and incremental symptom scores before the start (t = 60 min) and at the end (t = 180 min) of stepwise hypoglycemic glucose clamps in 16 healthy subjects, comparing glyburide (10 mg orally) and placebo

PlaceboGlyburide
Glucagon (pmol/l)
 Start9 ± 18 ± 1
 End38 ± 1*29 ± 3*
GH (mU/l)
 Start0.3 (0.2–2)0.8 (0.1–2)
 End30 (21–41)23 (14–37)
Cortisol (umol/l)
 Start0.25 ± 0.040.24 ± 0.05
 End0.64 ± 0.050.56 ± 0.05
Epinephrine (nmol/l)
 Start0.1 ± 0.020.3 ± 0.02
 End3.1 ± 0.263.4 ± 0.35
Norepinephrine (nmol/l)
 Start1.4 (1.2–1.7)1.4 (1.0–2.0)
 End2.3 (1.9–2.7)2.6 (2.1–3.3)
Symptom score (points)
 Start1 (0–8)2 (0–5)
 End8 (1–35)15 (3–22)
  • Hormonal data are means ± SEM, geometric mean (95% CI) (for GH and norepinephrine), or median (range) (for data for symptom scores).

  • *

    * P < 0.04