Table 4—

Novel cardiovascular risk factors before and after treatment with metformin or troglitazone

Metformin (n=12)
Troglitazone (n=10)
Metformin vs. Troglitazone (P)
BeforeAfterPBeforeAfterP
Fibrinogen (mg/dl)295±22270±190.46309±21287±210.460.97
CRP (mg/l)6±14±1<0.018±33±1<0.010.04
PAI-1 (ng/ml)74±2464±170.6893±2672±250.190.15
Lp (a)* (mg/dl)22±724±80.8433±1347±18<0.01<0.01
  • Data are means ±SEM. Statistical comparisons are based on percentage of change.

  • *

    * One outlier was excluded from the metformin group for lipemic sample.