Table 2—

Age-, sex-, and ethnicity-adjusted mean levels of baseline cardiovascular risk factors across quintiles of HOMA-IR among participants in the SAHS (Phase II) who were free of diabetes and CVD

Cardiovascular risk factorQuintiles of HOMA-IR
P value for trend
1
2
3
4
5
Means(SE)Means(SE)Means(SE)Means(SE)Means(SE)
BMI (kg/m2)23.9(0.2)25.0(0.2)26.5(0.2)28.5(0.2)31.6(0.2)<0.0001
Waist circumference (mm)816.4(5.1)847.2(5.1)881.2(5.0)925.1(5.1)986.8(5.1)<0.0001
Waist-to-hip ratio (×100)84.7(0.3)85.8(0.3)87.4(0.3)88.8(0.3)90.4(0.3)<0.0001
Fasting glucose (mg/dl)81.0(0.4)83.1(0.4)84.6(0.4)87.0(0.4)92.8(0.4)<0.0001
2-h glucose (mg/dl)92.4(1.4)95.4(1.3)101.7(1.3)106.6(1.3)120.7(1.4)<0.0001
Fasting insulin (IU/ml)3.2(0.4)6.3(0.4)9.7(0.4)14.6(0.4)31.9(0.4)<0.0001
Total cholesterol (mg/dl)188.0(1.7)191.6(1.7)197.9(1.7)200.8(1.7)199.0(1.7)<0.0001
HDL cholesterol (mg/dl)51.7(0.6)49.3(0.6)47.8(0.6)45.0(0.6)41.2(0.6)<0.0001
LDL cholesterol (mg/dl)115.7(1.6)119.27(1.6)125.0(1.6)128.1(1.6)124.8(1.6)<0.0001
Triglyceride (mg/dl)105.7(4.1)116.6(4.0)129.7(4.0)145.4(4.0)187.2(4.0)<0.0001
Systolic BP (mmHg)114.9(0.6)116.5(0.6)118.3(0.6)119.3(0.6)123.0(0.6)<0.0001
Diastolic BP (mmHg)69.0(0.4)70.4(0.4)71.9(0.4)73.1(0.4)75.4(0.4)<0.0001
  • All P values for trend <0.0001. BP, blood pressure.