Table 2—

Baseline patient characteristics according to treatment group

AspirinControlVitamin EControl
n519512509522
Age (years)64.3 ± 7.664.2 ± 7.464.3 ± 7.564.1 ± 7.5
Sex
 Male246 (47.4)251 (49.0)253 (49.7)244 (46.7)
 Female273 (52.6)261 (51.0)256 (50.3)278 (53.3)
CV risk factors for inclusion
 Old age252 (48.6)244 (47.7)248 (48.7)248 (47.5)
 Hypertension343 (66.7)*300 (59.4)312 (62.0)331 (64.2)
 Family history49 (9.7)35 (7.1)38 (7.7)46 (9.1)
 Obesity175 (34.2)165 (33.1)164 (32.7)176 (34.5)
 Hypercholesterolemia179 (35.7)129 (26.3)146 (30.1)162 (32.0)
CV risk factors (n)
 One53 (10.2)56 (10.9)58 (11.4)51 (9.8)
 Two133 (25.6)176 (34.4)158 (31.0)151 (28.9)
 Three or more333 (64.2)280 (54.7)293 (57.6)320 (61.3)
Smoking
 Ex132 (25.6)125 (24.8)122 (24.1)135 (26.3)
 Current83 (16.1)85 (16.8)86 (17.0)82 (16.0)
CV drugs
 Antihypertensive drugs335 (64.6)289 (56.5)298 (58.6)326 (62.5)
 Lipid lowering68 (13.3)63 (12.6)65 (13.0)66 (12.9)
Diabetes treatment
 Diet alone141 (27.2)137 (26.8)133 (26.1)145 (27.8)
 Sulphonyloureas133 (25.6)135 (26.4)147 (28.9)121 (23.2)
 Metformin18 (3.5)17 (3.3)14 (2.8)21 (4.0)
 Sulphonyloureas + metformin169 (32.6)166 (32.4)162 (31.8)173 (33.1)
 Insulin + OHA47 (9.1)48 (9.4)44 (8.6)51 (9.8)
 Other11 (2.1)9 (1.8)9 (1.8)11 (2.1)
BMI (kg/m2)29.0 ± 5.229.1 ± 4.729.2 ± 5.328.9 ± 4.6
Systolic blood pressure (mmHg)148.8 ± 17.0148.6 ± 17.1149.0 ± 16.7148.4 ± 17.4
Diastolic blood pressure (mmHg)84.9 ± 9.184.8 ± 8.985.1 ± 8.784.6 ± 9.2
Total cholesterol (mg/dl)226.0 ± 46.2222.2 ± 41.5223.0 ± 42.1226.1 ± 45.8
HDL cholesterol (mg/dl)49.5 ± 16.850.2 ± 15.549.8 ± 16.549.9 ± 15.8
Triglycerides (mg/dl)177.4 ± 111.2172.8 ± 100.5176.9 ± 110.9173.3 ± 100.8
HbA1c (%)7.6 ± 2.07.6 ± 2.17.6 ± 2.27.6 ± 2.0
  • Data are means ± SD or n (%). CV, cardiovascular; OHA, oral hypoglycemic agents.

  • * P < 0.05;

  • P < 0.01.