Table 1—

Demographics of the DCCT/EDIC cohort in 1997–1999 divided by prior DCCT treatment group and by gender

Intensive (n = 500)
PConventional (n = 468)
P
WomenMenWomenMen
n225275203265
Age (years)39.9 ± 7.339.9 ± 6.7NS38.4 ± 6.840.2 ± 6.6<0.01
Duration of type 1 diabetes (years)17.6 ± 4.617.5 ± 4.8NS17.8 ± 5.216.8 ± 4.6<0.05
BMI (kg/m2)26.8 ± 4.727.3 ± 4.2NS25.9 ± 3.927.0 ± 3.6<0.005
Waist-to-hip ratio0.8 ± 0.10.9 ± 0.1<0.00010.8 ± 0.10.9 ± 0.1<0.0001
HbA1c (% hemoglobin)8.2 ± 1.48.1 ± 1.3NS8.2 ± 1.48.3 ± 1.3NS
Mean HbA1c during DCCT (% hemoglobin)7.3 ± 0.97.2 ± 0.9NS9.1 ± 1.49.0 ± 1.1NS
Systolic blood pressure (mmHg)117 ± 14121 ± 12<0.0005115 ± 13124 ± 14<0.0001
Diastolic blood pressure (mmHg)73 ± 976 ± 9<0.000572 ± 977 ± 10<0.0001
Total cholesterol (conventional profile; mg/dl)189 ± 33190 ± 37NS187 ± 33189 ± 36NS
HDL cholesterol (conventional profile; mg/dl)63 ± 1651 ± 14<0.000163 ± 1452 ± 12<0.0001
LDL cholesterol (conventional profile; mg/dl)111 ± 29119 ± 31<0.01109 ± 29118 ± 31<0.005
Triglycerides (conventional profile; mg/dl)76 ± 3798 ± 67<0.000178 ± 5796 ± 73<0.01
AER (mg/24 h)49 ± 50093 ± 696NS74 ± 288160 ± 7420.09
Serum creatinine (mg/dl)0.8 ± 0.11.0 ± 0.2<0.00010.8 ± 0.21.0 ± 0.2<0.0001
Blood urea nitrogen (mg/dl)13.0 ± 3.615.1 ± 4.9<0.000113.2 ± 4.415.5 ± 4.8<0.0001
Standard creatinine clearance (ml/min)111 ± 25121 ± 23<0.0001110 ± 24119 ± 25<0.0005
ETDRS Score3.3 ± 2.43.6 ± 2.50.105.3 ± 3.75.7 ± 3.6NS
Hard exudate score2.3 ± 7.13.6 ± 9.50.096.2 ± 11.69.1 ± 13.5<0.05
% Current smoker20.9 (6.0)20.3 (5.4)NS17.3 (6.4)18.3 (5.6)NS
% BMI >27.3 in women, >27.8 in men (kg/m2)39.3 (5.3)38.5 (4.8)NS28.2 (6.0)36.3 (4.9)0.1
% WHR >0.85 in women, >0.90 in men14.6 (6.2)42.2 (4.6)<0.00019.0 (6.7)41.8 (4.7)<0.0001
% Hypertension26.1 (5.8)42.1 (4.6)<0.000526.2 (6.0)47.3 (4.5)<0.0001
% Taking any hypertensive medications9.1 (6.4)13.2 (5.6)NS17.8 (6.4)21.4 (5.5)NS
% AER >40 mg/24 h6.8 (6.5)11.5 (5.7)0.116.8 (6.4)20.5 (5.5)NS
% Taking ACE inhibitor6.7 (6.4)12.4 (5.6)<0.0513.8 (6.5)17.7 (5.6)NS
% Taking lipid-lowering medications4.0 (6.5)7.3 (5.8)NS3.9 (6.9)6.0 (6.0)NS
  • Data are mean ± SD or % (SD).