Table 3—

Standard lipid profile, NMR-determined lipoprotein profile, apolipoprotein levels in sera, and response to in vitro oxidation of LDL from women and men of the DCCT/EDIC cohort in 1997–1999

Intensive (n = 500)
PP1Conventional (n = 468)
PP1
WomenMenWomenMen
n225275203265
Conventional total cholesterol (mg/dl)189.0 ± 32.9190.0 ± 37.0NSNS187.1 ± 33.4188.7 ± 35.6NSNS
Conventional total triglyceride (mg/dl)75.7 ± 36.998.2 ± 67.5<0.0001NS78.0 ± 57.196.2 ± 72.7<0.005NS
Conventional LDL cholesterol (mg/dl)110.9 ± 29.3118.8 ± 31.3<0.01<0.05108.8 ± 29.4118.1 ± 31.2<0.005NS
Conventional HDL cholesterol (mg/dl)63.0 ± 15.651.2 ± 13.8<0.0001<0.000162.7 ± 13.651.7 ± 11.7<0.0001<0.005
NMR Large VLDL subclass (TG, mg/dl)5.8 ± 12.112.9 ± 27.7<0.001NS6.4 ± 14.712.4 ± 31.6<0.01NS
NMR Medium VLDL subclass (TG, mg/dl)14.9 ± 17.932.1 ± 39.2<0.0001<0.0516.5 ± 24.928.9 ± 35.7<0.0001NS
NMR Small VLDL subclass (TG, mg/dl)16.1 ± 14.622.4 ± 15.2<0.0001<0.0115.5 ± 15.622.1 ± 15.8<0.00010.08
NMR IDL subclass (cholesterol, mg/dl)2.0 ± 4.41.3 ± 2.9<0.05NS2.6 ± 4.81.5 ± 4.1<0.01<0.005
NMR L3 subclass (cholesterol, mg/dl)68.4 ± 35.454.8 ± 42.30.0001NS69.4 ± 34.855.3 ± 37.6<0.0001NS
NMR L2 subclass (cholesterol, mg/dl)32.0 ± 33.843.7 ± 37.4<0.001<0.0528.6 ± 34.240.8 ± 33.80.0001NS
NMR L1 subclass (cholesterol, mg/dl)26.1 ± 27.131.6 ± 37.30.06NS26.3 ± 30.231.7 ± 37.00.080.08
NMR Large HDL subclass (cholesterol, mg/dl)42.3 ± 15.428.7 ± 14.8<0.0001<0.000142.8 ± 14.129.1 ± 13.7<0.0001<0.001
NMR Small HDL subclass (cholesterol, mg/dl)14.8 ± 6.620.0 ± 6.3<0.0001<0.000114.6 ± 6.819.8 ± 6.1<0.0001<0.001
NMR VLDL particle size (nm)51.8 ± 20.147.4 ± 12.8<0.005<0.0552.4 ± 22.048.4 ± 14.6<0.05<0.005
NMR LDL particle size (nm)21.0 ± 0.520.8 ± 0.7<0.0001NS21.1 ± 0.620.8 ± 0.6<0.0001NS
NMR HDL particle size (nm)9.2 ± 0.58.8 ± 0.4<0.0001<0.00019.3 ± 0.48.9 ± 0.4<0.0001<0.05
NMR LDL particle concentration (nmol/l)1426 ± 3681490 ± 439<0.05NS1408 ± 3941467 ± 425NS<0.05
ApoB (mg/dl)84.9 ± 24.893.2 ± 27.2<0.001NS82.3 ± 23.290.2 ± 25.6<0.001NS
ApoA-I (mg/dl)148.6 ± 33.5137.5 ± 29.70.0001<0.01147.8 ± 30.1138.0 ± 26.9<0.001NS
  • Data are mean ± SD. Subjects are divided according to gender. The first set of four columns relates to the previously intensively managed cohort, and the second set relates to the group previously receiving conventional diabetes management. P = univariate analysis. P1 = ANCOVA: dependent variable is specified lipid, lipoprotein or apolipoprotein, independent parameter is gender, adjusted for age, duration of diabetes hypertension, HbA1c, BMI, WHR, and AER in each DCCT randomization group.