Table 2

Association between MetS and brain MRI in participants with symptomatic arterial disease (n = 1,232)

Global brain atrophy (BPF, %) B (95% CI)Subcortical brain atrophy (VF, %)
B (95% CI)ln WMH (%)
B (95% CI)LIs (n = 232)
OR (95% CI)Non-LIs (n = 216)
OR (95% CI)
MetS
 Model 1−0.72 (−0.97, −0.47)*0.08 (−0.02, 0.18)0.04 (−0.07, 0.16)1.03 (0.76, 1.39)1.27 (0.94, 1.72)
 Model 2−0.67 (−0.91, −0.42)*0.07 (−0.03, 0.17)0.01 (−0.10, 0.13)0.98 (0.70, 1.37)1.33 (0.94, 1.90)
Individual componentsa
 Impaired glucose metabolism−0.70 (−0.95, −0.45)*0.09 (−0.01, 0.20)0.05 (−0.07, 0.17)0.95 (0.70, 1.28)1.05 (0.77, 1.44)
 Elevated blood pressure−0.29 (−0.61, 0.04)0.11 (−0.02, 0.24)0.13 (−0.02, 0.27)2.37 (1.43, 3.92)*2.30 (1.40, 3.78)*
 Low HDL cholesterol−0.18 (−0.44, 0.08)−0.03 (−0.13, 0.08)0.08 (−0.04, 0.20)0.72 (0.52, 1.01)0.88 (0.63, 1.22)
 Elevated triglycerides−0.37 (−0.62, −0.12)*0.02 (−0.08, 0.12)−0.03 (−0.15, 0.09)1.01 (0.74, 1.38)1.20 (0.88, 1.63)
 Abdominal obesity−0.45 (−0.72, −0.19)*0.06 (−0.05, 0.16)0.02 (−0.11, 0.14)1.09 (0.79, 1.51)1.28 (0.93, 1.75)
  • Non-LIs include cortical, large subcortical, or infratentorial infarcts. Model 1 is adjusted for age and sex. Model 2 is as model 1 but additionally adjusted for current smoking and alcohol intake, IMT, and history of cerebrovascular disease.

  • aAdjusted for age and sex.

  • *P < 0.01.