Table 3—

Bivariate and multivariate regression analyses of serum adiponectin levels on metabolic factors, inflammatory markers, and vascular reactivity*

Parametersβ1β2β3β4
Metabolic factors
    Total cholesterol (mg/dl)0.030.02−0.05−0.05
    LDL cholesterol (mg/dl)−0.04−0.04−0.09−0.08
    HDL cholesterol (mg/dl)0.370.400.310.31
    Triglycerides (mg/dl)−0.22−0.22−0.17−0.17
Inflammatory markers
    ICAM (ng/ml)0.170.190.210.19
    ET1 (pg/ml)0.150.150.240.21
    TNF-α (pg/ml)−0.13−0.14−0.06−0.05
    CRP (mg/dl)*−0.22−0.25−0.07−0.20
    PAI-1 (ng/ml)−0.36−0.36−0.24−0.21
    tPA (ng/ml)−0.26−0.26−0.15−0.15
Vascular reactivity
    FR−0.11−0.14−0.002−0.02
    FMD0.004−0.003−0.020.004
    NID−0.03−0.05−0.040.01
    ACH%−0.09−0.12−0.12−0.10
    NNP%0.010.0030.040.05
  • β1, bivariate standardized linear regression coefficient; β2, multivariate standardized linear regression coefficient adjusted for sex; β3, multivariate standardized linear regression coefficient adjusted for sex and BMI; β4, multivariate standardized linear regression coefficient adjusted for sex, BMI, and HbA1c. FMD, flow-mediated dilation percentage increase over baseline (endothelium-dependent reactivity of macrocirculation); FR, resting brachial artery diameter (in millimeters).

  • *

    * Logarithmic transformation performed before analysis.

  • P < 0.01;

  • P < 0.025.