Parameters | β1 | β2 | β3 | β4 |
---|---|---|---|---|
Metabolic factors | ||||
Total cholesterol (mg/dl) | 0.03 | 0.02 | −0.05 | −0.05 |
LDL cholesterol (mg/dl) | −0.04 | −0.04 | −0.09 | −0.08 |
HDL cholesterol (mg/dl) | 0.37† | 0.40† | 0.31‡ | 0.31† |
Triglycerides (mg/dl) | −0.22‡ | −0.22‡ | −0.17 | −0.17 |
Inflammatory markers | ||||
ICAM (ng/ml) | 0.17 | 0.19 | 0.21 | 0.19 |
ET1 (pg/ml) | 0.15 | 0.15 | 0.24 | 0.21 |
TNF-α (pg/ml) | −0.13 | −0.14 | −0.06 | −0.05 |
CRP (mg/dl)* | −0.22‡ | −0.25† | −0.07 | −0.20 |
PAI-1 (ng/ml) | −0.36† | −0.36† | −0.24‡ | −0.21 |
tPA (ng/ml) | −0.26† | −0.26† | −0.15 | −0.15 |
Vascular reactivity | ||||
FR | −0.11 | −0.14 | −0.002 | −0.02 |
FMD | 0.004 | −0.003 | −0.02 | 0.004 |
NID | −0.03 | −0.05 | −0.04 | 0.01 |
ACH% | −0.09 | −0.12 | −0.12 | −0.10 |
NNP% | 0.01 | 0.003 | 0.04 | 0.05 |
β1, bivariate standardized linear regression coefficient; β2, multivariate standardized linear regression coefficient adjusted for sex; β3, multivariate standardized linear regression coefficient adjusted for sex and BMI; β4, multivariate standardized linear regression coefficient adjusted for sex, BMI, and HbA_{1c}. FMD, flow-mediated dilation percentage increase over baseline (endothelium-dependent reactivity of macrocirculation); FR, resting brachial artery diameter (in millimeters).
↵* Logarithmic transformation performed before analysis.
↵† P < 0.01;
↵‡ P < 0.025.