Parameters | β1 | β2 | β3 | β4 |
---|---|---|---|---|
Metabolic factors | ||||
Total cholesterol (mg/dl) | −0.004 | −0.01 | 0.02 | 0.02 |
LDL cholesterol (mg/dl) | 0.11 | 0.11 | 0.13 | 0.13 |
HDL cholesterol (mg/dl) | −0.28† | −0.33† | −0.33‡ | −0.33† |
Triglycerides (mg/dl) | 0.03 | 0.04 | 0.01 | 0.01 |
Inflammatory markers | ||||
ICAM (ng/ml) | −0.02 | −0.01 | −0.06 | −0.05 |
ET1 (pg/ml) | 0.22 | 0.22 | 0.23 | 0.25 |
TNF-α (pg/ml) | 0.01 | 0.01 | −0.02 | −0.01 |
CRP (mg/dl)* | 0.28† | 0.29† | 0.38† | 0.39† |
PAI-1 (ng/ml) | 0.12 | 0.13 | 0.10 | 0.13 |
tPA (ng/ml) | 0.08 | 0.08 | 0.03 | 0.03 |
Vascular reactivity | ||||
FR | 0.17 | 0.22 | 0.18 | 0.17 |
FMD | −0.13 | −0.13 | −0.12 | −0.12 |
NID | −0.17 | −0.17 | −0.18 | −0.17 |
ACH% | 0.06 | 0.07 | 0.07 | 0.08 |
NNP% | 0.07 | 0.06 | 0.05 | 0.05 |
β1, bivariate standardized linear regression coefficient; β2, multivariate standardized linear regression coefficient adjusted for sex; β3, multivariate standardized linear regression coefficient adjusted for sex and BMI; β4, multivariate standardized linear regression coefficient adjusted for sex, BMI, and HbA_{1c}. FMD, flow-mediated dilation percentage increase over baseline (endothelium-dependent reactivity of macrocirculation); FR, resting brachial artery diameter (in millimeters).
↵* Logarithmic transformation performed before analysis;
↵† P < 0.01;
↵‡ P < 0.025.