Table 2—

Clinical characteristics according to the Leu7Pro polymorphism of the NPY gene in all patients

All
Male
Female
Leu7LeuPro7/−PLeu7LeuPro7/−PLeu7LeuPro7/−P
n (%)866 (87)129 (13)469 (87)69 (13)397 (87)60 (13)
BMI (kg/m2)25.1 ± 0.125.8 ± 0.40.03725.3 ± 0.325.7 ± 0.20.41324.8 ± 0.225.9 ± 0.20.029
Waist-to-hip ratio0.880 ± 0.0030.887 ± 0.008NS0.927 ± 0.0040.930 ± 0.008NS0.824 ± 0.0040.837 ± 0.010NS
Coronary heart disease68 (8)17 (14)0.04347 (11)9 (14)0.44721 (5)8 (14)0.017
Acute myocardial infarction44 (5)9 (7)NS31 (7)7 (10)NS13 (3)2 (3)NS*
Stroke33 (4)4 (3)1.000*29 (6)1 (1)0.157*4 (1)3 (5)0.050*
Antihypertensive medication525 (63)78 (62)NS322 (71)44 (66)NS203 (52)34 (58)NS
HbA1c (%)8.5 ± 0.08.8 ± 0.10.0048.6 ± 0.38.9 ± 0.10.0688.3 ± 0.18.8 ± 0.20.024
Total cholesterol (mmol/l)5.20 ± 0.015.39 ± 0.11NS5.17 ± 0.055.38 ± 0.15NS5.22 ± 0.065.40 ± 0.16NS
HDL cholesterol (mmol/l)1.51 ± 0.021.52 ± 0.05NS1.37 ± 0.021.34 ± 0.05NS1.69 ± 0.031.74 ± 0.09NS
LDL cholesterol (mmol/l)3.10 ± 0.033.07 ± 0.09NS3.15 ± 0.053.15 ± 0.11NS3.03 ± 0.052.98 ± 0.15NS
Triglycerides (mmol/l)1.35 ± 0.031.65 ± 0.110.0031.49 ± 0.051.77 ± 0.190.1351.19 ± 0.031.50 ± 0.110.003
  • Data are means ± SE or n (%).

  • *

    * Fisher’s exact two-tailed test.

  • P = 0.005, P = 0.047, and P = 0.048 in all, male, and female, respectively, when adjusted for BMI.

  • P = 0.029, P = 0.275, and P = 0.028 in all, male, and female, respectively, when adjusted for HbA1c.