Table 2—

Blood pressure by treatment group regardless of pharmacologic therapy

Blood pressure (mmHg)Placebo
Metformin
Intensive lifestyle
SystolicDiastolicSystolicDiastolicSystolicDiastolic
Baseline (means ± SD)123.5 ± 14.478.0 ± 9.2124.0 ± 14.978.2 ± 9.5123.7 ± 14.878.6 ± 9.2
Change at year 1−0.90 ± 0.4−0.89 ± 0.2−0.91 ± 0.4*−1.26 ± 0.2*−3.4 ± 0.4*−3.6 ± 0.2*
Change at year 2−0.52 ± 0.4−1.07 ± 0.2−0.94 ± 0.4*−1.06 ± 0.2*−3.4 ± 0.4*−3.33 ± 0.2*
Change at year 3−0.57 ± 0.5−1.88 ± 0.3−0.29 ± 0.5*−1.59 ± 0.3*−3.27 ± 0.5*−3.82 ± 0.3*
  • Data are means ± SE unless otherwise noted.

  • *

    * P < 0.001 vs. placebo for changes in mean over time.