Table 2—

Baseline characteristics of subjects by IAA status

Not confirmed IAA ≥80Confirmed IAA ≥80P value
n109263
Median age13.0 (9–18)9.0 (6–12)0.0000
Average FPIR (μU/ml) (SD)172.1 ± 73.1155.3 ± 91.40.0878
Race0.9246
    White96 (88.0)231 (87.8)
    African American2 (1.8)5 (1.9)
    Hispanic7 (6.4)15 (5.7)
    Other4 (3.6)12 (4.5)
Sex0.0445
    Male57 (52.2)167 (63.5)
    Female52 (47.7)96 (36.5)
Relationship to index patient with diabetes0.1649
    Sibling58 (53.2)162 (61.6)
    Offspring31 (28.4)71 (27.0)
    Parent9 (8.2)9 (3.4)
    Second degree11 (10.0)21 (7.9)
Antibody levels
    Median ICAs (JDF units)40 (20–160)80 (40–320)0.0001
    Mean IAAs (nU/ml)72.0 ± 72.3485.2 ± 547.50.0000
GAD antibodies0.0461
    Positive74 (68.5)206 (78.3)
    Negative34 (31.4)57 (21.6)
ICA-512 antibodies0.0043
    Positive44 (40.7)150 (57.0)
    Negative64 (59.2)113 (42.9)
Micro IAA0.0000
    Positive4 (5.0)63 (31.9)
    Negative76 (95.0)134 (68.0)
HbA1c (%)5.33 ± 0.375.35 ± 0.360.6112
C-peptide area under curve
    During intravenous glucose tolerance test40.1 (16.7)32.8 (15.4)0.0001
    During oral glucose tolerance test563.9 (225.0)476.6 (189.1)0.0002
    During mixed-meal tolerance test443.2 (183.3)365.2 (169.5)0.0000
  • Data are means ± SD, n (%), or mean (interquartile range).