Table 1—

Smoking status at screening and prior to study visits, as indicated by serum cotinine and plasma carboxyhemoglobin levels

Serum cotinine level (ng/ml)Carboxyhemoglobin (%)
Nonsmokers (n = 10)
    Screening<10 (<10)0.6 (0.4–1.1)
    Cross-over visit 1<10 (<10)0.2 (0.2–0.8)
    Cross-over visit 2<10 (<10–15)0.2 (0.2–1.2)
Smokers (n = 20)
    Screening303 (120–466)4.8 (2.7–9.2)
    Cross-over visit 1297 (149–522)3.8 (1.9–15.2)
    Cross-over visit 2282 (184–489)3.9 (2.2–6.6)
    INH2Sm visit276 (124–494)2.3 (1.6–3.9)
    INH3Sm visit<29 (<10–71)0.8 (0.4–2.9)
    INH4Sm visit<10 (<10–13)0.5 (0.9–1.4)
    INH5Sm visit243 (114–402)2.7 (1.6–3.8)
  • Data are median (range).