Table 3

Unadjusted and adjusted continuous relationships between MRI ICVs and kidney disease phenotypes

MRI volume, adjusted for ICVKidney disease phenotype, analysis modelEstimate*SEP valuePredictor effect sizeAge effect size
CSF volumeeGFR, unadjusted−0.330.062.1 × 10−8
eGFR, adjusted−−0.050.06
UACR, unadjusted0.140.060.02
UACR, adjusted0.
CKD, unadjusted0.210.100.04
CKD, adjusted0.340.120.0060.370.06
GM volumeeGFR, unadjusted0.190.060.001
eGFR, adjusted−−0.01−0.05
UACR, unadjusted−
UACR, adjusted−−0.03−0.05
CKD, unadjusted−
CKD, adjusted−0.330.140.02−0.34−0.05
WM volumeeGFR, unadjusted0.140.060.02
eGFR, adjusted0.−0.01
UACR, unadjusted−
UACR, adjusted−−0.004−0.01
CKD, unadjusted0.010.110.95
CKD, adjusted−−0.02−0.01
WML volumeeGFR, unadjusted− × 10−6
eGFR, adjusted−−0.020.03
UACR, unadjusted0.170.060.007
UACR, adjusted0.220.065.0 × 10−40.030.04
CKD, unadjusted0.280.110.009
CKD, adjusted0.450.140.0020.280.04
  • Adjustment reflects age, education, sex, BMI, HbA1c level, and hypertension.

  • * Estimate of the change in each MRI outcome corresponding to increases of 100 mg/g in UACR and 10 mL/min/1.73 m2 in eGFR, and the presence of CKD (vs. no CKD).