Table 4

Unadjusted and adjusted continuous relationships between hippocampal volumes and kidney disease phenotypes

MRI hippocampal volume, adjusted for ICVKidney disease phenotype, analysis modelEstimate*SEP valuePredictor effect sizeAge effect size
Hippocampal CSF volumeeGFR, unadjusted−0.270.061.1 × 10−5
eGFR, adjusted−0.100.060.12−0.060.05
UACR, unadjusted0.220.063.6 × 10−4
UACR, adjusted0.190.068.2 × 10−40.040.06
CKD, unadjusted0.310.110.004
CKD, adjusted0.400.130.0030.440.06
Hippocampal GM volumeeGFR, unadjusted0.200.060.001
eGFR, adjusted0.110.080.160.05−0.03
UACR, unadjusted0.000.060.94
UACR, adjusted0.040.070.610.003−0.04
CKD, unadjusted−0.120.110.26
CKD, adjusted−0.230.160.15−0.23−0.04
Hippocampal WM volumeeGFR, unadjusted0.240.061.2 × 10−4
eGFR, adjusted0.190.080.0160.08−0.03
UACR, unadjusted−0.240.061.1 × 10−4
UACR, adjusted−0.270.071.6 × 10−4−0.05−0.04
CKD, unadjusted−0.200.110.07
CKD, adjusted−0.400.160.01−0.39−0.04
  • Adjustment reflects age, education, sex, BMI, HbA1c level, and hypertension.

  • * Estimate of the change in each MRI outcome corresponding to increases of 100 mg/g in UACR and 10 mL/min/1.73 m2 in eGFR, and the presence of CKD (vs. no CKD).