Table 1—

Changes observed from baseline for metabolic and phenotypic parameters

Period 1
Period 2
Sulfonylurea + placeboSulfonylurea + placeboSulfonylurea + CrPic
Glycemia
    Fasting glucose (mg/dl)−19.98 ± 5.330.0009−11.33 ± 8.03NS−31.00 ± 7.370.0002
    GHb (%)−1.07 ± 0.260.0006−0.44 ± 0.43NS−1.16 ± 0.380.0049
    Glucose AUC−7,794 ± 12380.0001−6,454 ± 22890.0092−11,131 ± 21080.0001
    Glucose AUC-B−2,531 ± 8730.008−2,501 ± 1412NS−3,981 ± 12690.0043
Insulin
    Glucose disposal (mg/min per fat-free mass)21.9 ± 11.8NS15.9 ± 18.5NS28.9 ± 11.30.0209
    Insulin AUC3,460 ± 5220.00012,969 ± 11020.0133,498 ± 9850.0016
    Insulin AUC-B2,604 ± 5180.00011,618 ± 7540.0422,022 ± 6570.0052
    Fasting C-peptide (ng/ml)−0.007 ± 0.030NS0.136 ± 0.111NS0.173 ± 0.093NS
Indirect calorimetry
    Respiratory quotient0.005 ± 0.006NS−0.006 ± 0.010NS0.005 ± 0.009NS
    REE53.74 ± 28.1NS59.43 ± 40.3NS29.14 ± 36.4NS
DEXA scans
    % fat0.22 ± 0.44NS1.17 ± 0.310.00080.12 ± 0.35NS
    Fat-free mass0.59 ± 0.40NS0.68 ± 0.46NS1.07 ± 0.440.0227
Lipids/adipocytokines
    FFAs (mmol/l)−0.12 ± 0.050.018−0.12 ± 0.050.028−0.20 ± 0.050.0007
    Triglycerides (mg/dl)11.43 ± 13.04NS3.68 ± 18.86NS30.32 ± 18.19NS
    Log (Triglycerides)0.09 ± 0.07NS0.06 ± 0.090NS0.13 ± 0.087NS
    Adiponectin (mg/ml)2.06 ± 0.600.0020.74 ± 0.75NS0.93 ± 0.702NS
  • Data are means ± SE or P values. REE, resting energy expenditure.