Table 2—

β-Cell function parameters and their univariate correlation with pancreatic fat

Nondiabetic subjectsType 2 diabetic subjectsPancreatic fat content (log %)
All subjects
Nondiabetic subjects
Type 2 diabetic subjects
RPRPRP
Empirical parameters of β-cell function
    Insulinogenic index adjusted for insulin resistance (ΔI0–30/ΔG0–30/HOMA-IR)98 ± 1811 ± 3*−0.606<0.001−0.6440.0010.201NS
    Early-phase insulin secretion (nmol/m2)8.9 ± 0.75.3 ± 0.4*−0.3480.038−0.162NS−0.407NS
    Late-phase insulin secretion (nmol/m2)40.1 ± 3.528.1 ± 2.6−0.145NS0.084NS−0.366NS
    Total insulin secretion (nmol/m2)49.0 ± 3.733.4 ± 2.8−0.186NS0.046NS−0.403NS
Model parameters of β-cell function
    Insulin secretion at the reference glucose level (pmol/min per m2)161 ± 18124 ± 13§NANA−0.6190.001−0.310NS
    β-Cell glucose sensitivity (pmol/min/m2/mmol/l)122 ± 1530 ± 3*−0.580<0.001−0.5950.0020.100NS
    Rate sensitivity (pmol/m2/mmol/l)1,107 ± 131194 ± 42*−0.4110.014−0.326NS−0.081NS
    Potentiation factor1.5 ± 0.21.0 ± 0.1−0.147NS−0.071NS0.134NS
  • Data are means ± SE unless otherwise indicated. For calculations of the various β-cell parameters, see research design and methods.

  • *

    * P < 0.001;

  • P < 0.05;

  • P < 0.02.

  • §

    § Parameter calculated at 5 and 7 mmol/l glucose for nondiabetic and type 2 diabetic subjects, respectively.

  • Not comparable with control subjects because of different reference glucose level. NA, not applicable because of different reference glucose level; NS, not significant; R, Pearson's correlation coefficient.