Table 4

Plasma phospholipid n-3 FAs modify the association between incident type 2 diabetes and serum NEFAs, presented as HRs (95% CIs), MESA, N = 5,697

Quartiles of NEFAsPtrend
Quartile, n1 (n = 1,380)2 (n = 1,461)3 (n = 1,455)4 (n = 1,401)
Range0.13–0.390.40–0.520.53–0.670.68–2.11
Pinteraction = 0.03
Low n-3 (<75th percentile)*
 Cases, n92127147157
 Model 1, HR (95% CI)1.01.41 (1.07, 1.84)1.77 (1.35, 2.31)2.18 (1.65, 2.88)<0.001
 Model 2, HR (95% CI)1.01.30 (1.00, 1.70)1.51 (1.15, 1.98)1.83 (1.39, 2.43)<0.001
High n-3 (≥75th percentile)*
 Cases, n32393429
 Model 1, HR (95% CI)1.01.17 (0.72, 1.89)1.01 (0.60, 1.70)0.96 (0.55, 1.66)0.85
 Model 2, HR (95% CI)1.01.00 (0.61, 1.63)0.89 (0.53, 1.51)0.80 (0.46, 1.40)0.83
  • Model 1 adjusted for age, sex, race, education, field center, smoking, and alcohol use. Model 2 adjusted for model 1 plus waist circumference and hs-CRP.

  • *Low n-3 FA category <75th percentile; high n-3 FA category ≥75th percentile.