Table 1

Baseline characteristics of participants stratified by the presence of peripheral neuropathy in the PROMISE cohort

Neuropathy −Neuropathy +*P value
n (%)307 (65.7)160 (34.3)
Age (years)51 (45–58)57 (48–64)0.0001
Female sex75.667.50.06
Ethnicity0.08
 Caucasian70.471.9
 South Asian5.548.75
 Hispanic14.77.50
 Other9.4511.9
Current smoker4.65.60.3
Heavy drinker11.813.10.7
Family history of diabetes60.167.50.1
BMI (kg/m2)30.4 (26.6–34.4)30.7 (27.8–35.1)0.3
Height (cm)164 (159–171)166 (160–174)0.07
Waist circumference (cm)98.2 (88.3–108)101 (91.0–110)0.04
Systolic blood pressure (mmHg)125 (115–135)125 (117–136)0.3
Plasma triglycerides (mmol/L)1.23 (0.95–1.65)1.27 (1.00–1.81)0.3
HDL cholesterol (mmol/L)1.3 (1.1–1.6)1.3 (1.0–1.5)0.4
Fasting blood glucose (mmol/L)5.1 (4.8–5.6)5.3 (4.9–5.7)0.03
2-h postload blood glucose (mmol/L)5.9 (4.8–7.3)6.7 (5.4–8.5)0.0001
VPT (V)5.2 (3.8–7.2)6.5 (5.1–9.9)0.0001
  • Data are median (interquartile range) or % unless otherwise indicated.

  • *The presence of neuropathy was defined as >2 out of a total MNSI score of 10.