Table 2—

Prevalence of virulence determinants among the 132 S. aureus strains isolated from diabetic foot ulcers during inclusion and follow-up

Virulence genotypingGrade 1Grade 2Grade 3Grade 4P value
Grade 1 vs. Grade 2Grade 1 vs. G*
n26354526
sea3 (12)16 (46)29 (64)14 (54)0.015<0.001
seb0 (0)2 (6)7 (16)7 (27)0.041
sec0 (0)5 (14)4 (9)9 (35)0.023
sed7 (27)16 (46)18 (40)12 (46)
see0 (0)0 (0)0 (0)0 (0)
seg6 (23)10 (29)18 (40)16 (62)
seh1 (4)3 (9)3 (7)1 (4)
sei5 (19)12 (34)20 (44)18 (69)0.014
sej4 (15)14 (40)12 (27)8 (31)0.049
sek0 (0)3 (9)1 (2)3 (12)
seq0 (0)3 (9)1 (2)2 (8)
tst2 (8)4 (11)7 (16)12 (46)
etA0 (0)1 (3)2 (4)1 (4)
etB0 (0)0 (0)0 (0)0 (0)
luk-PV0 (0)0 (0)2 (4)3 (12)
lukE7 (27)23 (66)23 (51)17 (65)0.0040.004
hlb7 (27)17 (49)29 (64)17 (65)0.004
hlg3 (12)23 (66)36 (80)21 (81)<0.001<0.001
hlgv2 (8)21 (60)35 (78)20 (77)<0.001<0.001
edinC0 (0)0 (0)0 (0)0 (0)
bbp1 (4)5 (14)7 (16)6 (23)
cna3 (12)4 (11)5 (11)8 (31)
ebpS3 (12)7 (20)13 (29)12 (46)
clfA22 (85)30 (86)36 (80)23 (89)
clfB20 (77)31 (89)32 (71)24 (92)
fib16 (62)20 (57)27 (60)20 (77)
fnbA5 (19)14 (40)13 (29)13 (50)
fnbB13 (50)21 (60)19 (42)17 (65)
eno26 (100)35 (100)45 (100)26 (100)
cap59 (35)23 (66)28 (62)16 (62)0.0210.014
cap815 (58)5 (14)6 (13)3 (12)0.0190.002
agr110 (39)24 (69)21 (47)13 (50)
agr210 (39)5 (14)11 (24)6 (24)
agr36 (23)4 (11)7 (16)7 (27)
agr40 (0)2 (6)6 (13)0 (0)
MRSA5 (19)12 (34)20 (44)14 (54)0.021
  • Data are n (%) unless otherwise indicated.

  • *

    * G corresponds to grades 2–4 according to the IWGDF classification system (3,4).