Table 2—

Baseline spirometry by diabetes status and adjusted differences in adults with diabetes versus without diabetes at baseline

FVC (ml)FEV1 (ml)FVC % predictedFEV1 % predictedFEV1-to-FVC ratio (%)
No diabetes3,873 (3,863 to 3,882)2,911 (2,904 to 2,919)102.8 (102.6 to 103.1)96.5 (96.3 to 96.8)75.4 (75.3 to 75.5)
Diabetes3,740 (3,711 to 3,769)2,839 (2,856 to 2,863)98.3 (98.5 to 100.1)94.1 (93.3 to 94.9)76.2 (75.8 to 76.5)
Diabetes vs. no diabetes−133 (−163 to −103)−72 (−97 to −47)−3.6 (−4.4 to −2.7)−2.4 (−3.2 to −1.6)0.8 (0.4 to 1.1)
P value<0.0001<0.0001<0.0001<0.0001<0.0001
Diabetes, by fasting glucose
    <140 mg/dl vs. no diabetes−109 (−155 to −63)−66 (−105 to −29)−2.9 (−4.1 to −1.7)−2.3 (−3.5 to −1.0)0.4 (−0.1 to 0.9)
    140–199 mg/dl vs. no diabetes−147 (−202 to −93)−81 (−127 to −36)−3.8 (−5.3 to −2.4)−2.6 (−4.1 to −1.1)0.9 (−0.2 to 0.1)
    200 + vs. no diabetes−155 (−216 to −94)−69 (−120 to −19)−4.2 (−5.7 to −2.6)−2.4 (−4.1 to −0.8)1.3 ( 0.6 to 1.9)
Ptrend*<0.0001<0.0001<0.0001<0.0001<0.0001
Diabetes, by duration
    ≤5 years vs. no diabetes−105 (−166 to −43)−27 (−78 to 24)−2.8 (−4.5 to −1.2)−1.1 (−2.7 to 0.6)1.3 (0.7 to 2.0)
    6–9 years vs. no diabetes−153 (−249 to −56)−77 (−158 to 3)−3.9 (−6.4 to −1.4)−2.5 (−5.1 to 0.1)1.0 (−0.02 to 2.1)
    ≥10 years vs. no diabetes−155 (−224 to −86)−86 (−144 to −29)−4.0 (−5.8 to −2.2)−2.8 (−4.7 to −0.9)0.8 (0.01 to 1.5)
    Unknown vs. no diabetes−135 (−175 to −95)−84 (−118 to −51)−3.7 (−4.7 to −2.6)−2.8 (−3.9 to −1.8)0.5 (0.05 to 0.94)
Ptrend in known duration*<0.00010.0005<0.00010.00050.0002
Diabetes, by medications
    No medication vs. no diabetes−112 (−154 to −77)−70 (−100 to −36)−3.0 (−4.0 to −2.0)−2.2 (−3.2 to −1.1)0.5 (0.1 to 1.0)
    Oral agents vs. no diabetes−141 (−198 to −84)−56 (−103 to −9)−3.7 (−5.2 to −2.2)−2.0 (−3.5 to −0.4)1.3 (0.7 to 1.9)
    Insulin (alone or with oral) vs. no diabetes−187 (−257 to −117)−112 (−170 to −53)−5.3 (−7.1 to −3.4)−4.0 (−5.9 to −2.1)0.9 (0.1 to 1.6)
Ptrend*<0.0001<0.0001<0.0001<0.0001<0.0001
  • Data are means (95% CI) adjusted for baseline age, sex, race, height, BMI, waist circumference, pack-years of smoking, sport activity index, education level, and ARIC center.

  • *

    * P values correspond to tests for linear trend across categories.