Table 3—

Adjusted changes in FVC, FEV1, and FEV1-to-FVC ratio over 3 years of follow-up by diabetes status at baseline

ΔFVC (ml/year)Δ FEV1 (ml/year)Δ FVC % predicted (%/year)Δ FEV1 % predicted (%/year)Δ FEV1-to-FVC ratio (%/year)
No diabetes↓58 (56–59)↓47 (45–48)↓0.96 (0.9–1.0)↓0.7 (0.7–0.8)↓0.1 (0.07–0.1)
Diabetes↓64 (59–69)↓49 (46–53)↓1.1 (1.0–1.3)↓0.9 (0.7–1.0)↓0.05 (−0.02–0.1)
P value0.010.130.0090.080.22
Diabetes by fasting glucose
    <140 mg/dl↓63 (53–72)↓49 (42–56)↓1.1 (0.8–1.3)↓0.8 (0.6–1.0)↓0.1 (−0.03–0.2)
    140–199 mg/dl↓61 (52–69)↓47 (40–53)↓1.1 (0.9–1.3)↓0.8 (0.6–1.0)↓0.1 (−0.1–0.2)
    200+ mg/dl↓56 (46–65)↓47 (40–54)↓0.9 (0.7–1.2)↓0.8 (0.5–1.0)↓0.2 (0.01–0.3)
Ptrend*0.590.890.650.880.83
Diabetes by duration
    ≤5 years↓57 (48–67)↓45 (38–52)↓1.0 (0.7–1.3)↓.7 (0.5–1.0)↓0.1 (−0.1–0.1)
    6–9 years↓63 (47–79)↓52 (40–63)↓1.1 (0.7–1.5)↓0.9 (0.5–1.3)↓0.1 (−0.3–0.1)
    ≥10 years↓68 (57–79)↓50 (41–58)↓1.3 (1.0–1.6)↓0.9 (0.6–1.2)↑0.03 (−0.1–0.2)
    Unknown↓65 (59–72)↓51 (46–56)↓1.2 (1.0–1.3)↓0.9 (0.7–1.1)↓0.1 (−0.2–0.0)
Ptrend in known duration*0.070.420.050.310.11
Diabetes by medications
    No medication↓63 (57–69)↓48 (44–53)↓1.1 (0.9–1.3)↓0.8 (0.7–1.0)↓0.1 (−0.02–0.1)
    Oral agents↓57 (48–66)↓50 (43–57)↓1.0 (0.7–1.2)↓0.9 (0.6–1.1)↓0.2 (0.1–0.3)
    Insulin (alone or with oral)↓79 (68–90)↓52 (44–61)↓1.5 (1.2–1.9)↓0.9 (0.6–1.2)↑0.2 (−0.4 −0.1)
Ptrend*0.0010.400.0010.330.0003
  • Data are means (95% CI) adjusted for baseline age, sex, race, height, BMI, waist circumference, pack-years of smoking, sport activity index, education level, baseline lung function, BMI change from baseline to year 3, waist change from baseline to year 3, incident asthma or chronic lung disease or use of medications for the conditions at 3-year follow-up, and ARIC center.

  • *

    * P values correspond to tests for linear trend across categories.