Table 2—

Features of metabolic syndrome and parameters of glycemic control and β-cell function

LADA with insulinLADA without insulinType 2 diabetes with insulinType 2 diabetes without insulinP
Difference between LADA with and without insulinDifference between LADA and type 2 diabetes with insulinDifference between type 2 diabetes with and without insulin
Systolic blood pressure (mmHg)150 (144–157)158 (152–163)157 (154–160)157 (155–158)0.1020.0860.897
Diastolic blood pressure (mmHg)81 (77–85)84 (81–88)85 (83–87)86 (85–87)0.1990.0820.256
BMI (kg/m2)28.7 (27.4–30.1)28.4 (27.3–29.5)30.9 (30.2–31.5)29.5 (28.8–29.5)0.696<0.001<0.001
Waist circumference (cm)94.5 (91.1–97.9)93.7 (90.9–96.4)99.8 (98.2–101.4)95.8 (95.0–96.6)0.7210.0050.001
Cholesterol-to–HDL cholesterol ratio4.7 (4.1–5.3)5.5 (5.0–6.0)5.8 (5.5–6.0)5.6 (5.4–5.7)0.0540.0010.235
Fasting blood glucose11.3 (10.1–12.5)9.8 (8.9–10.7)11.5 (11.0–12.0)8.9 (8.7–9.2)0.0490.746<0.001
A1C9.1 (8.7–9.7)8.0 (7.6–8.4)8.8 (8.6–9.0)7.7 (7.6–7.8)0.0010.175<0.001
C-peptide (pmol/l)130 (105–160)682 (577–806)377 (343–416)787 (749–827)<0.001<0.001<0.001
C-peptide in subjects without sulfonylurea (pmol/l)122 (97–152)700 (542–904)368 (332–409)796 (736–862)<0.001<0.001<0.001
  • Data are means (95% CI), adjusted for age, sex, and diabetes duration. No significant differences were found between LADA and type 2 diabetes not treated with insulin.