Table 1

Baseline patient characteristics

Dapagliflozin dose
PlaceboMetformin
2.5 mg5 mg10 mg20 mg50 mg
Age (years)55 ± 1155 ± 1254 ± 955 ± 1053 ± 1053 ± 1154 ± 9
Sex
    Male (%)29 (49)28 (48)25 (53)32 (54)25 (45)30 (56)27 (48)
    Female (%)30 (51)30 (52)22 (47)27 (46)31 (55)24 (44)29 (52)
A1C (%)7.6 ± 0.78.0 ± 0.98.0 ± 0.87.7 ± 0.97.8 ± 1.07.9 ± 0.97.6 ± 0.8
FPG (mg/dl)145 ± 34153 ± 48148 ± 38149 ± 41153 ± 42150 ± 46143 ± 33
PPG (mg · min/dl)42,225 ± 9,73344,416 ± 9,88544,283 ± 12,07142,625 ± 7,42644,822 ± 10,24443,867 ± 12,83242,109 ± 8,554
24-h urinary glucose (g/24 h)6 ± 166 ± 1411 ± 3110 ± 358 ± 257 ± 218 ± 20
24-h urinary glucose/creatinine (g/g)4.8 ± 126.3 ± 206.1 ± 146.7 ± 247.6 ± 236.9 ± 266 ± 16
24-h urine volume (liters)2.2 ± 0.91.9 ± 0.81.9 ± 0.91.8 ± 0.81.8 ± 0.82.0 ± 1.01.9 ± 1.0
Weight (kg)90 ± 2089 ± 1786 ± 1788 ± 1892 ± 1989 ± 1888 ± 20
BMI (kg/m2)32 ± 532 ± 531 ± 531 ± 532 ± 432 ± 532 ± 5
sBP (mmHg)127 ± 14126 ± 13127 ± 16127 ± 15126 ± 16126 ± 16126 ± 13
dBP (mmHg)78 ± 876 ± 877 ± 877 ± 877 ± 977 ± 878 ± 8
Heart rate (beats/min)71 ± 1070 ± 1069 ± 868 ± 1070 ± 1072 ± 1168 ± 10
Creatinine (mg/dl)0.85 ± 0.150.83 ± 0.190.85 ± 0.170.88 ± 0.190.84 ± 0.20.85 ± 0.190.82 ± 0.17
BUN (mg/dl)15.3 ± 4.214.6 ± 4.114.3 ± 3.615.6 ± 4.214.6 ± 4.614.5 ± 3.214.4 ± 3.3
Sodium (mEq/l)137.6 ± 2.5137.7 ± 2.8137.6 ± 1.9137.8 ± 2.5138.0 ± 2.6137.7 ± 2.7137.8 ± 2.2
Potassium (mEq/l)4.2 ± 0.44.1 ± 0.44.1 ± 0.34.2 ± 0.34.1 ± 0.54.1 ± 0.44.2 ± 0.5
Calcium (mg/dl)9.3 ± 0.49.2 ± 0.49.3 ± 0.49.3 ± 0.49.2 ± 0.59.3 ± 0.49.2 ± 0.4
Magnesium (mEq/l)1.7 ± 0.11.7 ± 0.21.7 ± 0.21.7 ± 0.11.6 ± 0.21.7 ± 0.21.7 ± 0.2
Phosphate (mg/dl)3.8 ± 0.63.7 ± 0.63.6 ± 0.63.8 ± 0.43.7 ± 0.63.7 ± 0.53.7 ± 0.6
Uric acid (mg/dl)5.5 ± 1.25.2 ± 1.35.5 ± 1.25.3 ± 1.35.6 ± 1.45.5 ± 1.45.0 ± 1.3
  • Data are means ± SD.