Table 2

Hyperfiltration, albuminuria, and histological findings

eGFRUrine ACR (mg/mmol)Focal segmental glomerulosclerosisGlobal glomerulosclerosisMesangial proliferationImmunofluorescenceOther pathological findings
1156>270*MildMesangial and capillary loop IgG, IgA, IgM, C3, C1qSubepithelial and mesangial deposits, epimembranous spikes
2204662/12 perihilar1/12MildMesangial IgAFocal mild chronic tubulointerstitial damage
31621051/25Negative
4144613/9 perihilar1/9NegativeMild-moderate chronic tubulointerstitial damage
5415172/19MildMesangial and capillary loop IgG, IgA, IgM, C3, C1qParamesangial deposits and mesangial sclerosis
61941781/221/22NegativeMild GBM thickening, capsular drop
72151171/221/22Negative
81902151/14 tip lesionMinimalMesangial IgAFocal arteriolosclerosis
91182905/13 perihilar1/13NegativeMild-moderate chronic tubulointerstitial damage
10210231/18Segmental mildMesangial IgAFocal arteriolosclerosis, mild GBM thickening
  • *Estimated based on proteinuria of 3.6 g/day.

  • †Persistent macroalbuminuria documented in these patients; ACR most proximal to time of biopsy demonstrated microalbuminuria.

  • ‡eGFR (ml/min per 1.73 m2) estimated by calculation of size-adjusted creatinine clearance using the Schwatrz formula. When ACR >200 mg/mmol, the urine total protein-to-creatinine ratio is reported. GBM, glomerular basement membrane.