Table 4

Multivariable-adjusted linear regression models for relation of SAT, VAT, or BMI to inflammatory markers

Multivariable model*
Multivariable model with SAT or VAT adjusted for BMI or with BMI adjusted for both SAT and VAT
R2PLog difference ± SE per SD (% change)R2PLog difference ± SE per SD (% change)
CRP (mg/l)
    SAT0.23<0.00010.148 ± 0.026 (41)0.260.070.063 ± 0.034
    VAT0.160.0030.088 ± 0.029 (22)0.240.90.003 ± 0.031
    BMI0.24<0.00010.159 ± 0.023 (44)0.260.0010.132 ± 0.039 (36)
ICAM-1 (ng/ml)
    SAT0.090.050.025 ± 0.0130.090.70.007 ± 0.017
    VAT0.090.0010.046 ± 0.013 (11)0.090.0080.040 ± 0.015 (10)
    BMI0.060.030.025 ± 0.0110.100.50.014 ± 0.019
MCP (pg/ml)
    SAT0.100.9−0.001 ± 0.0160.100.7−0.008 ± 0.022
    VAT0.130.0010.057 ± 0.017 (14)0.110.0010.061 ± 0.019 (15)
    BMI0.090.20.017 ± 0.0140.120.6−0.013 ± 0.024
VCAM-1 (mg/ml)
    SAT0.070.5−0.007 ± 0.010.070.8−0.003 ± 0.013
    VAT0.070.30.010 ± 0.0110.090.010.027 ± 0.011 (6)
    BMI0.070.3−0.009 ± 0.0090.090.1−0.021 ± 0.015
Fibrinogen (mg/dl)
    SAT0.140.020.018 ± 0.0080.150.50.008 ± 0.011
    VAT0.120.20.011 ± 0.0090.130.8−0.001 ± 0.01
    BMI0.130.0030.022 ± 0.007 (5)0.150.20.017 ± 0.012
MMP9 (ng/ml)
    SAT0.140.10.021 ± 0.0130.150.9−0.002 ± 0.018
    VAT0.140.030.033 ± 0.0150.150.20.020 ± 0.017
    BMI0.140.010.031 ± 0.012 (7)0.170.20.027 ± 0.020
PAI-1 (ng/ml)
    SAT0.120.30.015 ± 0.0160.140.4−0.019 ± 0.021
    VAT0.18<0.00010.074 ± 0.017 (19)0.17<0.00010.055 ± 0.017 (14)
    BMI0.130.020.033 ± 0.0140.170.30.023 ± 0.024
IL-6 (pg/ml)
    SAT0.160.0010.058 ± 0.017 (14)0.170.30.021 ± 0.022
    VAT0.100.070.025 ± 0.0160.140.8−0.006 ± 0.02
    BMI0.15<0.00010.069 ± 0.015 (17)0.170.010.062 ± 0.025 (15)
  • *Multivariable model is adjusted for age, sex, diabetes therapy, duration of diabetes, years of smoking, statin use, and A1C.

  • †Percent change in inflammatory markers for every 1-SD increase in VAT, SAT, or BMI.