Table 2

Association of glycemic groups to diffuse and focal brain changes: AGES–Reykjavik

Normoglycemic*IFGType 2 diabetes
Tissue volume
    Total brain volume
        Model 172.1972.2771.45
        Model 272.2572.2571.46
    Grey matter
        Model 145.1045.2844.86
        Model 245.1245.3044.93
    White matter
        Model 125.7725.6825.11
        Model 225.7225.7325.28
    WMLs
        Model 11.311.311.47
        Model 21.311.291.42
Cerebral infarcts
    Model 1
        Single infarct1.01.00 (0.85–1.17)1.71 (1.37–2.15)
        Multiple infarcts1.01.13 (0.87–1.48)2.65 (1.90–3.69)
    Model 2
        Single infarct1.00.97 (0.82–1.14)1.45 (1.14–1.85)
        Multiple infarcts1.01.13 (0.86–1.49)2.27 (1.60–3.23)
  • Data are adjusted mean percentage of total intracranial volume or ORs (95% CI). n = 4,415. Model 1 was adjusted for age, sex, and education. Model 2 included additional adjustments for myocardial infarction, smoking status, hypertension, BMI, and physical activity.

  • *Reference group is normoglycemic subjects.

  • P < 0.01;

  • P < 0.001.