Table 1

MDR results of multi-locus interaction

Best modelTesting balance accuracyCross-validation consistencyPP*
Male subjects
    Mas0.471480.98930.804
    Mas, BDKRB20.475950.82810.375
    ACE2-A, ACE, Mas0.6195100.01070.172
    ACE2-A, ACE, Mas, AGT0.562490.05470.043
    ACE2-A, ACE, Mas, AGT, BDKRB20.539960.17190.6010
Female subjects
    ACE2-B0.536490.17190.516
    ACE2-A, ACE0.556790.17190.068
    ACE2-A, ACE, AGTR20.5892100.00100.012
    ACE2-B, ACE, Mas, AGTR20.531960.17190.341
    ACE2-A, ACE, Mas, AGT, AGTR20.558690.05470.148
  • *P based on 1,000 permutations. Data in bold represent statistical significance. Genotypes: AGT (rs699) C/T; ACE (I/D); ACE2-A (rs2106809) G/A; ACE2-B (rs2074192) C/T; AGTR1 (rs5186) A/C; AGTR2 (rs1403543) A/G; Mas (rs220721) A/G; BDKRB2 (rs1799722) C/T.