Table 3

Glycemic indices

Age ≥25 years (n = 74)*Age 15–24 years (n = 55)*Age 8–14 years (n = 44)*
Baseline (blinded)Month 6PBaseline (blinded)Month 6PBaseline (blinded)Month 6P
Glucose (mg/dl)157 ± 25152 ± 180.08165 ± 27173 ± 280.02172 ± 29169 ± 280.50
    Minimum/day 71–180 mg/dl882980<0.0018227880.147978120.18
Hypoglycemia
    Minimum/day (mg/dl)
        ≤7055450.0293550.00556370.61
        ≤6020170.00649230.00119110.23
        ≤50540.021940.008210.61
    AUC†0.30.30.0080.70.30.0020.40.20.42
    LBGI0.90.90.021.50.90.0041.00.80.56
Hyperglycemia
    Minimum/day (mg/dl)
        >1804393900.034945820.035695680.37
        >2002962560.0043814360.034604520.23
        >25011472<0.00011662100.072181930.58
    AUC‡15.112.1<0.00121.725.00.0625.323.90.43
    HBGI6.85.80.0028.29.40.049.69.60.45
Glycemic variability§
    SD (mg/dl)6054<0.001 (<0.001)67680.35 (0.38)66660.61 (0.95)
    MAGE (mg/dl)1101000.14 (0.35)1261240.44 (0.38)1291190.04 (0.06)
MARC (mg · dl−1 · min−1)0.650.680.13 (0.03)0.790.800.01 (0.16)0.750.770.72 (0.49)
Coefficient of variation (%)‖38360.002 (<0.001)41410.27 (0.32)41390.99 (0.90)
  • Data are means ± SD and medians unless otherwise indicated.

  • *n includes subjects with at least 24 h of data at both baseline and month 6.

  • †Total area <70 mg/dl, reflecting both percentage and severity of glucose values in the hypoglycemic range.

  • ‡Total area >180 mg/dl, reflecting both percentage and severity of glucose values in the hyperglycemic range.

  • §For variability, the P values unadjusted and adjusted for mean glucose are both given: unadjusted (adjusted).

  • ‖Coefficient of variation = SD/mean. AUC, area under the curve; LBGI, low blood glucose index (13); HBGI, high blood glucose index (13); MAGE, mean amplitude of glycemic excursions; MARC, mean absolute rate of change.