Table 2

Weight gain in antidepressant users and propensity score: matched nonusers

Antidepressant usersControlP value*
Any antidepressant
    n1,4044,133
    Weight at baseline (kg)70.5 (69.8–71.2)69.6 (69.2–70.0)0.02
    Weight at follow-up (kg)73.1 (72.4–73.8)71.0 (70.6–71.4)<0.0001
    Weight change between baseline and follow-up (kg)2.54 (2.28–2.80)1.37 (1.22–1.52)<0.0001
    Relative change in weight (%)4.25 (3.81–4.69)2.48 (2.22–2.74)<0.0001
SSRI
    n1,2103,563
    Weight at baseline (kg)70.6 (69.8–71.3)69.4 (69.0–69.9)0.007
    Weight at follow-up (kg)73.4 (72.6–74.2)70.8 (70.3–71.3)<0.0001
    Weight change between baseline and follow-up (kg)2.79 (2.52–3.07)1.38 (1.22–1.54)<0.0001
    Relative change in weight (%)4.63 (4.17–5.09)2.44 (2.16–2.71)<0.0001
Tricyclic antidepressants
    n140402
    Weight at baseline (kg)72.6 (70.3–74.9)70.1 (68.7–71.4)0.06
    Weight at follow-up (kg)75.3 (72.9–77.6)71.4 (70.0–72.8)0.005
    Weight change between baseline and follow-up (kg)2.70 (1.88–3.52)1.29 (0.81–1.77)0.004
    Relative change in weight (%)4.24 (2.91–5.57)2.34 (1.56–3.12)0.02
Other antidepressants
    n4221,237
    Weight at baseline (kg)70.6 (69.3–71.9)71.9 (71.1–72.6)0.08
    Weight at follow-up (kg)73.0 (71.6–74.3)73.5 (72.7–74.3)0.49
    Weight change between baseline and follow-up (kg)2.42 (1.93–2.91)1.65 (1.36–1.94)0.007
    Relative change in weight (%)4.15 (3.37–4.93)2.69 (2.23–3.15)0.002
  • Data are means (95% CI) unless otherwise indicated. Subjects were matched for depression and 14 related factors. Antidepressant use refers to a minimum use of 200 defined daily doses of antidepressants during 4 years.

  • *Multilevel analysis of variance.

  • †Mean ± SD follow-up 3.7 ± 0.9 years.

  • ‡Calculated for 4 years.