Table 1

Change in A1C from baseline* to month 6 by amount of CGM use in month 6 in subjects with A1C ≥7.0% at the time of initiation of CGM

AllCGM use in month 6
0 days/week>0–<4 days/week4–<6 days/week≥6 days/week
Overall
    n15426452360
    Baseline A1C (%)†7.88.07.77.87.6
    Change in A1C from baseline to month 6
        Mean change (%)−0.1 ± 0.6+0.2 ± 0.90.0 ± 0.6−0.4 ± 0.7−0.2 ± 0.4
        Improved ≥0.5%49 (32)8 (31)8 (18)13 (57)20 (33)
        Worsened ≥0.5%27 (18)8 (31)13 (29)2 (9)4 (7)
        A1C <7.0%29 (19)2 (8)5 (11)9 (39)13 (22)
    Mean change from 0–6 months in prior RCT0.0 ± 0.6−0.1 ± 0.5+0.1 ± 0.60.0 ± 0.7+0.1 ± 0.5
Age-group ≥25 years
    n5144637
    Baseline A1C (%)7.68.07.67.57.6
    Change in A1C from baseline to month 6
        Mean change−0.4 ± 0.5+0.1 ± 0.9−0.4 ± 0.7−0.5 ± 0.3−0.4 ± 0.4
        Improved ≥0.5%23 (45)1 (25)2 (50)4 (67)16 (43)
        Worsened ≥0.5%3 (6)1 (25)1 (25)01 (3)
        A1C <7.0%15 (29)02 (50)3 (50)10 (27)
    Mean change from 0–6 months in prior RCT+0.2 ± 0.5+0.4 ± 0.5+0.3 ± 0.6+0.3 ± 0.5+0.1 ± 0.4
Age-group 15–24 years
    n561126712
    Baseline A1C (%)7.98.17.98.17.7
    Change in A1C from baseline to month 6
        Mean change (%)0.0 ± 0.7+0.4 ± 1.20.0 ± 0.5−0.6 ± 0.30.0 ± 0.3
        Improved ≥0.5%14 (25)4 (36)4 (15)5 (71)1 (8)
        Worsened ≥0.5%10 (18)4 (36)5 (19)01 (8)
        A1C <7.0%6 (11)02 (8)3 (43)1 (8)
    Mean change from 0–6 months in prior RCT (%)+0.1 ± 0.7−0.1 ± 0.5+0.1 ± 0.6−0.1 ± 0.8+0.2 ± 0.7
Age-group 8–14 years
    n4711151011
    Baseline A1C (%)7.87.87.67.97.8
    Change in A1C from baseline to month 6
        Mean change (%)0.0 ± 0.7−0.1 ± 0.6+0.2 ± 0.6−0.2 ± 0.90.0 ± 0.6
        Improved ≥0.5%12 (26)3 (27)2 (13)4 (40)3 (27)
        Worsened ≥0.5%14 (30)3 (27)7 (47)2 (20)2 (18)
        A1C <7.0%8 (17)2 (18)1 (7)3 (30)2 (18)
    Mean change from 0–6 months in prior RCT (%)−0.2 ± 0.6−0.2 ± 0.4−0.1 ± 0.7−0.2 ± 0.7−0.1 ± 0.5
  • Data are means, means ± SD, or n (%).

  • *Baseline refers to the time of initiation of CGM use (following the 6 months in the RCT as control group).

  • †One subject was missing a baseline laboratory A1C, and the point-of-care A1C was imputed using a least squares regression model.