Table 1

Subject characteristics of each of the age- and BMI-matched groups

Subject characteristicsObese-NGTObese-type 2 diabeticANOVA
PrestudyPoststudyPrestudyPoststudyTimeTime-group
Age (years)63 ± 267 ± 2
Sex (male/female)8/86/7
Weight (kg)93.9 ± 3.288.8 ± 2.998.3 ± 4.693.4 ± 4.2<0.00010.90
BMI (kg/m2)32.1 ± 1.130.4 ± 1.235.5 ± 1.533.7 ± 1.3<0.00010.78
Fat (%)41.0 ± 1.639.0 ± 2.140.8 ± 2.038.5 ± 2.50.010.84
VAT (cm2)187 ± 16134 ± 15202 ± 28168 ± 27<0.00010.24
Vo2max (l/min)2.11 ± 0.122.35 ± 0.161.99 ± 0.152.25 ± 0.15<0.00010.97
Leptin (ng/ml)25.9 ± 4.819.9 ± 4.422.3 ± 4.718.5 ± 4.30.0070.40
TG (mg/dl)194 ± 28136 ± 19181 ± 17156 ± 190.0030.15
Cholesterol (mg/dl)199 ± 9178 ± 8192 ± 10182 ± 90.00060.24
A1C (%)5.35 ± 0.095.51 ± 0.085.86 ± 0.295.16 ± 0.320.080.008
FPG (mg/dl)97.9 ± 3.597.2 ± 3.0129 ± 7*116 ± 60.030.04
2-h OGTT (mg/dl)124 ± 3122 ± 7225 ± 11*192 ± 110.030.05
FPI (μU/ml)16.0 ± 2.013.7 ± 2.326.5 ± 7.117.4 ± 1.50.110.27
AUC I (× 103 μU/ml · 0.3 h)12.9 ± 1.67.6 ± 1.610.1 ± 2.311.5 ± 1.90.010.13
GDR (mg/kg/min)2.67 ± 0.263.91 ± 0.381.85 ± 0.37*2.34 ± 0.40<0.00010.03
  • Data are means ± SEM.

  • *Indicates significant difference vs. obese-NGT, P < 0.05. AUC I, area under the insulin response curve to the OGTT; FPI, fasting plasma insulin; GDR, glucose disposal rate during the hyperinsulinemic-euglycemic clamp; TG, triglycerides; VAT, intra-abdominal visceral adipose tissue.