Table 3

Incidence of microalbuminuria in subjects in different HOMA-IR quartiles, according to their glycemic and blood pressure control

HOMA-IR quartile at baselineDevelopment of microalbuminuria (n)Person-years observedMicroalbuminuria incidence per 1,000Incident RR (95% CI)P value*
Overall subjects (n = 738)
 Quartile 150771.664.81.00<0.001
 Quartile 262742.083.51.28 (0.88–1.87)
 Quartile 366716.292.11.42 (0.98–2.06)
 Quartile 469696.999.01.52 (1.06–2.20)
Cumulative average HbA1c ≤ 8% (n = 403)
 Quartile 127501.253.81.000.657
 Quartile 228452.361.91.14 (0.67–1.96)
 Quartile 335371.694.11.74 (1.05–2.91)
 Quartile 424336.971.21.32 (0.75–2.30)
Cumulative average HbA1c >8% (n = 335)
 Quartile 123270.485.01.000.043
 Quartile 234289.7117.41.38 (0.81–2.37)
 Quartile 338344.6110.31.29 (0.77–2.20)
 Quartile 445360.0125.01.47 (0.89–2.46)
Cumulative average BP ≤130/80 mmHg (n = 290)
 Quartile 123461.949.71.000.021
 Quartile 222283.677.51.55 (0.86–2.81)
 Quartile 325284.687.81.76 (0.99–3.13)
 Quartile 428293.295.51.91 (1.10–3.36)
Cumulative average BP >130/80 mmHg (n = 448)
 Quartile 127309.787.11.000.049
 Quartile 240458.487.21.00 (0.61–1.64)
 Quartile 341431.695.01.09 (0.67–1.79)
 Quartile 441403.7101.61.16 (0.71–1.91)
  • BP, blood pressure; RR, rate ratio.

  • *Test for trend for incidence rate ratio from HOMA-IR Q1 to Q4.