Table 2

Multivariate logistic regression for GADA, IA-2A, and GADA- and/or IA-2A–positive subjects*

CovariatesGADAIA-2AAby+
N% PosOR95% CI% PosOR95% CI% PosOR95% CI
Onset age 2–7 years
 Duration (years)
  0–553045.5161.3176.61
  6–1364434.80.620.49–0.8044.60.460.36–0.5962.30.470.36–0.61
  ≥ 1456527.60.440.34–0.5824.20.160.12–0.2142.70.200.15–0.26
Onset age 8–13 years
 Duration (years)
  0–574558.81.731.37–2.1965.11.170.91–1.5082.11.39§1.05–1.85
  6–1350841.90.860.67–1.1253.90.67§0.51–0.8771.90.74§0.55–0.99
  ≥ 1451437.00.68§0.52–0.8835.00.300.23–0.3956.20.360.27–0.48
Onset age ≥14 years
 Duration (years)
  0–556770.52.992.30–3.8953.40.73§0.56–0.9582.21.49§1.09–2.03
  6–1338965.32.251.69–3.0042.70.420.31–0.5673.80.820.60–1.13
  ≥ 1455842.50.900.70–1.1526.20.200.15–0.2653.40.340.26–0.45
HLA
 X/X37436.6130.2150.01
 DR3/X62749.61.941.42–2.6526.00.850.62–1.1657.31.50§1.11–2.04
 DR3/DR337457.02.611.84–3.7022.70.68§0.47–0.9965.22.111.49–2.99
 DR3/DR41,84747.92.031.54–2.6949.12.752.10–3.6170.23.142.39–4.13
 DR4/X1,27841.81.40§1.06–1.8656.73.582.71–4.7369.02.672.02–3.54
 DR4/DR452052.52.131.54–2.9459.84.173.04–5.7376.33.942.84–5.47
  • *Shown are the results of three separate multivariate analyses with dependent variables GADA, IA-2A, or Aby+. Independent variables (covariate) are age of onset (split into tertiles), duration of disease (split into tertiles), and HLA type. Aby+ indicates those who are GADA- and/or IA-2A–positive.

  • % Pos, percentage of antibody-positive subjects; X ≠ DR3 or DR4.

  • P < 0.001;

  • P < 0.0001;

  • §P < 0.05.