Table 2

Baseline A1C, complications, and mortality: overall population results*

OutcomeIncidence density (events per 1,000 person-years)Baseline A1C
Model<6.06.0–6.97.0–7.98.0–8.99.0–9.910–10.9≥11
Acute metabolic events1.23Unadjusted HR (95% CI)11.59 (0.97–2.60)2.86 (1.74–4.69)4.53 (2.66–7.73)6.34 (3.51–11.46)8.43 (4.34–16.40)12.36 (6.73–22.70)
Adjusted HR (95% CI)11.44 (0.82–2.53)2.35 (1.31–4.23)3.82 (2.03–7.18)4.95 (2.45–10.02)6.60 (2.99–14.56)11.52 (5.66–23.47)
Chronic microvascular events26.68Unadjusted HR (95% CI)11.56 (1.41–1.72)2.78 (2.51–3.08)4.17 (3.73–4.66)4.34 (3.79–4.97)4.94 (4.19–5.81)5.05 (4.29–5.94)
Adjusted HR (95% CI)11.11 (0.99–1.25)1.25 (1.11–1.41)1.53 (1.34–1.75)1.52 (1.29–1.79)1.72 (1.41–2.10)2.04 (1.68–2.47)
Chronic cardiovascular events47.15Unadjusted HR (95% CI)11.12 (1.05–1.19)1.28 (1.20–1.37)1.46 (1.35–1.59)1.48 (1.33–1.65)1.55 (1.34–1.79)1.80 (1.57–2.07)
Adjusted HR (95% CI)11.09 (1.01–1.17)1.14 (1.06–1.24)1.26 (1.14–1.39)1.28 (1.12–1.46)1.39 (1.17–1.66)1.77 (1.51–2.09)
Mortality40.42Unadjusted HR (95% CI)10.83 (0.79–0.88)0.82 (0.77–0.88)0.84 (0.78–0.92)0.92 (0.82–1.04)1.07 (0.92–1.25)1.12 (0.96–1.30)
Adjusted HR (95% CI)10.84 (0.79–0.90)0.83 (0.76–0.90)0.90 (0.81–1.00)1.02 (0.88–1.17)1.21 (1.01–1.45)1.31 (1.09–1.57)
Any complication69.90Unadjusted HR (95% CI)11.22 (1.16–1.29)1.66 (1.57–1.76)2.12 (1.98–2.26)2.22 (2.04–2.42)2.36 (2.11–2.65)2.51 (2.25–2.81)
Adjusted HR (95% CI)11.09 (1.02–1.16)1.18 (1.10–1.27)1.38 (1.27–1.50)1.42 (1.27–1.58)1.52 (1.32–1.74)1.86 (1.63–2.13)
Any complication or death97.97Unadjusted HR (95% CI)11.05 (1.01–1.10)1.30 (1.24–1.36)1.59 (1.51–1.69)1.68 (1.56–1.82)1.82 (1.65–2.01)1.92 (1.74–2.11)
Adjusted HR (95% CI)10.98 (0.93–1.03)1.03 (0.97–1.09)1.20 (1.12–1.29)1.25 (1.14–1.37)1.35 (1.20–1.52)1.63 (1.46–1.84)
  • *Cox proportional hazards models adjusted for age; sex; race/ethnicity; duration of diabetes; systolic blood pressure; use of insulin, sulfonylurea, or thiazolidinedione; smoking status; glucose-monitoring adherence; GFR (chronic kidney disease stages 1–5); microalbuminuria; and proteinuria.