Table 3

Multiple adjusted HRs of type 2 diabetes associated with a two-point increment in the rMED in population subgroups

Number of cases/number of subcohort*HR95% CIP for interaction
Sex0.144
 Male5,946/5,5970.960.93–1.00
 Female5,670/9,4520.950.91–0.98
Age (years)0.019
 <502,637/5,6811.000.94–1.06
 50–595,604/6,1190.950.91–0.98
 ≥603,753/3,2490.960.92–1.00
BMI (kg/m2)0.088
 <251,666/6,9360.920.88–0.97
 25–295,266/5,9870.950.92–0.98
 ≥305,062/2,1260.990.95–1.03
Smoking status0.393
 Never4,882/7,0380.950.92–0.99
 Former3,716/4,0380.970.92–1.01
 Current3,295/3,8270.960.92–1.01
History of diabetes in a first-degree relative§0.527
 No3,441/5,4740.920.88–0.96
 Yes1,935/1,1380.960.90–1.04
  • *Numbers in the subcohort exclude type 2 diabetic case subjects.

  • †Modified Cox proportional hazards regression models stratified by center and adjusted for sex, BMI (as a continuous variable), educational level (no formal education, primary school, technical/professional school, secondary school, and longer education including university degree), physical activity (inactive, moderately inactive, moderately active, and active), smoking status (never, former, and three categories of current smoker: 1–10 cigarettes day−1, 11–20 cigarettes day−1, and >20 cigarettes day−1), and total calorie intake (as a continuous variable).

  • ‡Heterogeneity among subgroups was tested by adding an interaction term in the model between these variables and rMED.

  • §Family history of diabetes was not ascertained in the centers in Italy, Spain, Germany, and Oxford.