Table 3

Adjusted spirometry results for normal, MS, and DM groups by inflammatory markers

FVC (mL)FEV1 (mL)FVC % predictedFEV1 % predictedFEV1-to-FVC ratio (%)
CRP
 Normal
  Low CRP3,652 (3,549–3,756)2,707 (2,622–2,792)99.1 (96.5–101.6)96.7 (94.1–99.3)74.4 (73.1–75.7)
  High CRP†3,541 (3,421–3,662)2,576 (2,477–2,675)96.8 (93.8–99.8)92.3 (89.2–95.3)72.7 (71.2–74.2)
  High CRP vs. low CRP−111 (−245 to 23)−131 (−241 to −21)−2.3 (−5.6 to 1.1)−4.4 (−7.8 to −1.0)−1.7 (−3.3 to 0)
  P value0.10430.01980.18350.01110.0521
 MS
  Low CRP vs. normal, low CRP−130 (−253 to −6)−82 (−181 to 16)−3.5 (−6.9 to −0.2)−3.5 (−6.9 to −0.1)0.2 (−1.3 to 1.7)
  High CRP vs. normal, low CRP−261 (−384 to −138)−135 (−233 to −37)−7.5 (−10.8 to −4.2)−5.2 (−8.5 to −1.8)1.5 (0 to 2.9)
  Ptrend value‡<0.00010.0024<0.00010.00070.0315
 DM
  Low CRP vs. normal, low CRP−211 (−335 to −87)−109 (−205 to −14)−4.7 (−8.2 to −1.2)−3.2 (−6.5 to 0.2)1.4 (−0.2 to 3.0)
  High CRP vs. normal, low CRP−254 (−372 to −136)−164 (−254 to −73)−7.4 (−10.7 to −4.1)−6.7 (−9.9 to −3.5)0.8 (−0.7 to 2.3)
  Ptrend value‡<0.0001<0.0001<0.0001<0.00010.2345
FIB
 Normal
  Low FIB3,640 (3,539–3,740)2,704 (2,622–2,785)98.7 (96.1–101.3)96.6 (94.0–99.2)74.6 (73.3–75.9)
  High FIB§3,612 (3,492–3,732)2,631 (2,534–2,728)98.4 (95.3–101.6)93.6 (90.6–96.7)72.8 (71.2–74.3)
  High FIB vs. low FIB−28 (−163 to 107)−73 (−182 to 37)−0.3 (−3.8 to 3.3)−3.0 (−6.4 to 0.5)−1.8 (−3.5 to −0.1)
  P value0.68330.19280.88400.09290.0415
 MS
  Low FIB vs. normal, low FIB−154 (−266 to −42)−73 (−163 to 17)−4.7 (−7.7 to −1.7)−3.7 (−6.7 to −0.6)0.8 (−0.5 to 2.1)
  High FIB vs. normal, low FIB−208 (−331 to −85)−130 (−228 to −32)−5.9 (−9.2 to −2.7)−5.0 (−8.4 to −1.7)0.5 (−0.9 to 2.0)
  Ptrend value‡0.00020.0036<0.00010.00090.4108
 DM
  Low FIB vs. normal, low FIB−178 (−290 to −67)−100 (−186 to −14)−4.3 (−7.4 to −1.2)−3.7 (−6.8 to −0.7)1.1 (−0.3 to 2.5)
  High FIB vs. normal, low FIB−295 (−407 to −182)−181 (−268 to −95)−8.7 (−11.8 to −5.5)−7.3 (−10.3 to −4.2)1.1 (−0.4 to 2.5)
  Ptrend value‡<0.00010.0001<0.0001<0.00010.1004
  • Data are means (95% CI) adjusted for age, sex, height, hypertension, physical activity index, education level, current smoking status, and SHS center. FIB, fibrinogen. †High CRP was defined as CRP >3.0 mg/L. ‡P values correspond to tests for linear trend across categories. §High fibrinogen was defined as plasma fibrinogen >350 mg/dL.