Table 3

DKA rates in children aged <5 years and <2 years at diagnosis

StudyTotal DKAMild DKASevere DKA
<2 years**P value<5 years**P value<2 years**P value<5 years**P value<2 years**P value<5 years**P value
TEDDY (strict DKA definition)*5/318/612/315/613/313/61
16.1%13.1%6.5%8.2%9.7%4.9%
(6.1–34.5)(6.2–24.8)(1.1–22.8)(3.1–18.8)(2.5–26.9)(1.3–14.6)
TEDDY (broad DKA definition)Ŧ6/409/793/406/793/403/79
15%11.3%7.5%7.6%7.5%3.8%
(6.3–30.5)(5.7–21.0)(2.0–21.5)(3.1–16.4)(2.0–21.5)(0.9–11.5)
Sweden registry*51/1290.02102/6040.4539/1290.00578/6040.4112/129124/6040.73
39.5%16.9%30.2%12.9%9.3%4.0%
(31.2–48.6)(14.0–20.2)(22.6–39.0)(10.4–15.9)(5.1–16.0)(2.6–5.9)
SEARCHŦ29/58<0.0001100/275<0.0001NANANANANANANANA
50.0%36.4%
(36.7–63.3)(30.7–42.4)
Finland registryŦ82/183<0.0001138/7370.1164/1830.0005114/7370.0618/1830.7724/7370.74
44.8%18.7%35.0%15.5%9.8%3.3%
(37.5–52.3)(16.0–21.8)(28.1–42.4)(12.9–18.1)(5.9–15.1)(2.1–4.8)
German registryŦ235/435<0.0001583/1,812<0.0001171/435<0.0001458/1,812<0.000164/4350.34125/1,8120.36
54%32.2%39.3%25.3%14.7%6.9%
(49.2–58.8)(30.0–34.4)(34.7–44.1)(23.3–27.4)(11.6–18.5)(5.8–8.2)
  • NA, data not available.

  • **N cases/sample population denominator, prevalence (95% confidence intervals).

  • *All comparisons made to TEDDY strict definition.

  • ŦAll comparisons made to TEDDY broad definition.