Table 1

ADA evidence grading system for clinical practice recommendations

Level of evidenceDescription
AClear evidence from well-conducted, generalizable, RCTs that are adequately powered, including:
  • Evidence from a well-conducted multicenter trial

  • Evidence from a meta-analysis that incorporated quality ratings in the analysis

Compelling nonexperimental evidence, i.e., “all or none” rule developed by Center for Evidence Based Medicine at Oxford
Supportive evidence from well-conducted randomized controlled trials that are adequately powered, including:
  • Evidence from a well-conducted trial at one or more institutions

  • Evidence from a meta-analysis that incorporated quality ratings in the analysis

BSupportive evidence from well-conducted cohort studies
  • Evidence from a well-conducted prospective cohort study or registry

  • Evidence from a well-conducted meta-analysis of cohort studies

Supportive evidence from a well-conducted case-control study
CSupportive evidence from poorly controlled or uncontrolled studies
  • Evidence from RCTs with one or more major or three or more minor methodological flaws that could invalidate the results

  • Evidence from observational studies with high potential for bias (such as case series with comparison with historical controls)

  • Evidence from case series or case reports

Conflicting evidence with the weight of evidence supporting the recommendation
EExpert consensus or clinical experience