Table 2

Type 1 diabetes stage 1 and 2 intervention clinical trials

StageTrialClinicalTrials.gov identifierAgentTarget populationStatusReference
1DENIS; ENDIT NicotinamideOral nicotinamideCompletedLampeter et al. (127), Gale et al. (128)
1DPT-1NCT00004984Oral insulinAt-risk relativesCompletedSkyler et al. (32)
Oral insulin
1DIPPNCT00223613Intranasal insulinAt-risk childrenCompletedNäntö-Salonen et al. (129)
Intranasal insulin
1Belgian Diabetes Registry Parenteral insulinParenteral insulinAt-risk relativesCompletedVandemeulebroucke et al. (130)
1DiAPREV-ITNCT01122446Parenteral GAD-alumAt-risk childrenFollow-upAndersson et al. (131)
1DiAPREV-IT2NCT02387164Parenteral GAD-alum; oral vitamin D3At-risk childrenRecruiting
1TrialNetNCT00419562Oral insulinAt-risk relativesRecruiting
Oral insulin
1TrialNetNCT01773707Parenteral abataceptAt-risk relativesRecruiting
CTLA4-Ig
1DVDCNCT00336674Intranasal insulinAt-risk relativesRecruiting
INIT II
2DPT-1NCT00004984Parenteral insulinAt-risk relativesCompletedDPT-1 Study Group (4)
Parenteral insulin
2TrialNetNCT01030861Parenteral teplizumabAt-risk relativesRecruiting
Anti-CD3
  • DVDC, Diabetes Vaccine Development Centre; INIT II, Intranasal Insulin Trial.