Table 2

Assessment using NP-MOT at baseline and then 12 months after starting SU therapy in 8 patients younger than 4 years of age at baseline (patient nos. 1–8)

Abnormal at baselineAbnormal after 12 months of SUMedian score difference (range)
Tone
 Passive tone6 (75)1 (12.5)−1 (−1 to 0), P = 0.06**
Improved n = 5
Stable n = 1
Still normal n = 2
 Standing tone (score <8)6 (75)0 (0%)2 (0−6), P = 0.03**
Improved n = 6
Still normal n = 2
Motricity
 Gross motor skills (delay >2 months)3 (37.5)1 (12.5)2 (−7 to 3), P = 0.19**
Improved n = 3
Degradation n = 1
Still normal n = 4
 Fine motor skills (delay >2 months)5 (62.5)2 (25)1 (−5.5 to 3.5), P = 0.07**
Improved n = 3
Stable n = 2
Still normal n = 3
Attention
 Attention3 (37.5)1 (12.5)P = 0.48*
Improved n = 2
Stable n = 1
Still normal n = 5
 Hyperactivity2 (33.3)0
Improved n = 2
Still normal n = 6
  • Data are n (%) unless otherwise indicated. The value presented in the parentheses in the last column is the range of score differences in values for the patients. The lowest score is −1 and 0 is the highest.

  • *McNemar χ2 test;

  • **Paired Wilcoxon test on continuous scores.