Table 3

Relationships between brain volumes with subclinical CVD

Outcome (cm3)PredictorAdjustmentParameter estimateSEP valueEffect
GMVAorCPTICV, age, sex, African ancestry, time from CT scan to MRI scan−0.110.032.0 × 10−4−1.91
GMVAorCPAbove + smoking, BMI, HbA1c, use of statins, hypertension, prior CVD−0.100.031.8 × 10−3−1.80
GMVCorCPTICV, age, sex, African ancestry, time from CT scan to MRI scan−0.500.144.0 × 10−4−2.0
GMVCorCPAbove + smoking, BMI, HbA1c, use of statins, hypertension, prior CVD−0.470.152.3 × 10−3−1.9
GMVCarCPTICV, age, sex, African ancestry, time from CT scan to MRI scan−2.030.611.0 × 10−3−1.64
GMVCarCPAbove + smoking, BMI, HbA1c, use of statins, hypertension, prior CVD−1.920.622.3 × 10−3−1.57
WMVAorCPTICV, age, sex, African ancestry, time from CT scan to MRI scan4.1 × 10−61.8 × 10−60.021.37
WMVAorCPAbove + smoking, BMI, HbA1c, use of statins, hypertension, prior CVD4.9 × 10−61.9 × 10−60.011.50
WMVCorCPTICV, age, sex, African ancestry, time from CT scan to MRI scan2.3 × 10−58.2 × 10−65.0 × 10−31.72
WMVCorCPAbove + smoking, BMI, HbA1c, use of statins, hypertension, prior CVD2.6 × 10−58.7 × 10−63.3 × 10−31.95
WMVCarCPTICV, age, sex, African ancestry, time from CT scan to MRI scan8.5 × 10−53.5 × 10−50.021.25
WMVCarCPAbove + smoking, BMI, HbA1c, use of statins, hypertension, prior CVD8.9 × 10−53.6 × 10−50.011.25
WMLV*AorCPTICV, age, sex, African ancestry, time from CT scan to MRI scan6.0 × 10−64.1 × 10−50.88
WMLV*AorCPAbove + smoking, BMI, HbA1c, use of statins, hypertension, prior CVD−6.4 × 10−54.6 × 10−50.16
WMLV*CorCPTICV, age, sex, African ancestry, time from CT scan to MRI scan1.7 × 10−41.9 × 10−40.37
WMLV*CorCPAbove + smoking, BMI, HbA1c, use of statins, hypertension, prior CVD−6.6 × 10−52.0 × 10−40.74
WMLV*CarCPTICV, age, sex, African ancestry, time from CT scan to MRI scan5.1 × 10−41.1 × 10−30.63
WMLV*CarCPAbove + smoking, BMI, HbA1c, use of statins, hypertension, prior CVD3.7 × 10−41.1 × 10−30.74
  • AorCP, aorta CP; CarCP, carotid artery CP; CorCP, coronary artery CP; TICV, total ICV.

  • *Reflects the 227 scans performed on 3.0-T MRI scanners.

  • †Effect sizes are calculated for a quarter SD change in the predictor. SDs for aorta, carotid, and coronary CP are shown in Table 2.