Table 3

Multivariate logistic regression analysis of incident diabetes in relation to total HDL cholesterol and HDL cholesterol subclasses

Total HDL cholesterolHDL2 cholesterolHDL3 cholesterol
OR per 1-SD increment (95% CI)POR per 1-SD increment (95% CI)POR per 1-SD increment (95% CI)P
Age1.80 (1.29–2.50)<0.0011.75 (1.26–2.43)0.0011.80 (1.30–2.51)<0.001
Family history of diabetes2.08 (1.16–3.73)0.0142.12 (1.18–3.82)0.0122.02 (1.14–3.60)0.017
2-h plasma glucose4.00 (2.72–5.88)<0.0014.01 (2.72–5.90)<0.0013.94 (2.69–5.76)<0.001
HOMA-IR1.55 (1.17–2.04)0.0021.51 (1.14–1.99)0.0041.64 (1.25–2.15)<0.001
Total HDL cholesterol0.72 (0.52–0.995)0.047Not included in the modelNot included in the model
HDL2 cholesterolNot included in the model0.64 (0.44–0.93)0.018Not included in the model
HDL3 cholesterolNot included in the modelNot included in the model0.90 (0.67–1.19)0.44
  • Age, sex, BMI, waist circumference, family history of diabetes, systolic blood pressure, current smoking, alcohol consumption, regular physical activity, lipid-lowering medications, triglyceride, HOMA-IR, 2-h plasma glucose, and total HDL cholesterol, HDL2 cholesterol, or HDL3 cholesterol were included in each model.