Table 2

Laboratory and MRI lesion volumes of the AA-DHS MIND sample

VariableFull sample (n = 268)Aorta CP absent*(n = 58)Aorta CP present(n = 210)P value
nMean (SD) median or %nMean (SD) median or %nMean (SD) median or %
UACR at the MIND visit (mg/g)262148.64 (513) 9.154126.06 (423.36) 6.7208154.5 (534.57) 9.650.10
CKD-EPI eGFR at the MIND visit (mL/min/1.73 m2)26386.6 (24.59) 895592.56 (24.87) 9120885.03 (24.34) 860.08
CRP at CT visit (mg/dL)2561.04 (1.6) 0.57560.88 (1.06) 0.52001.08 (1.72) 0.590.72
Serum glucose at the MIND visit (g/dL)263146.75 (59.21) 13355152.09 (63.65) 139208145.34 (58.06) 131.50.63
HbA1c at the MIND visit (%)2627.94 (1.87) 7.4558.19 (2.22) 82077.88 (1.76) 7.30.57
Change in HbA1c between CT and MRI visits (%)259−0.09 (1.81) −0.1540.12 (1.74) 0.15205−0.14 (1.83) −0.10.27
HDL cholesterol (mg/dL)26647.83 (13.21) 465747.82 (13.24) 4420947.84 (13.23) 460.94
LDL cholesterol (mg/dL)264109.12 (36.38) 10656111.34 (32.13) 110208108.52 (37.49) 1030.39
Triglycerides (mg/dL)266121.97 (91.11) 99.557127.07 (138.75) 93209120.58 (73.37) 1010.62
Vitamin B12 (pg/mL)263673.41 (408.64) 56355605.67 (355.85) 506208691.32 (420.45) 573.50.19
Thyroid-stimulating hormone (μIU/mL)2632.01 (1.62) 1.65552.05 (1.39) 1.732081.99 (1.68) 1.640.53
Coronary artery CP (mass score, mg)268215.02 (502.90) 11.05811.39 (39.34) 0210266.90 (553.00) 27.02.7 × 10−8
Coronary CP >0 mg (%)26863.65841.321069.95.2 × 10−5
Carotid artery CP (mass score, mg)26736.46 (118.42) 0572.8 (12.36) 021045.6 (131.96) 02.6 × 10−6
Carotid artery CP >0 mg (%)26741.25715.7921048.11.2 × 10−5
Total intracranial volume (cm3)2681,291.37 (131.4) 1,279.91581,298.26 (132.94) 1,274.152101,289.47 (131.23) 1,283.260.88
CSFV (cm3)268247.33 (47.24) 240.4858224.56 (41.18) 216.34210253.61 (46.96) 244.975.7 × 10−6
GMV (cm3)268560.57 (56.11) 557.3158577.82 (55.36) 575.37210555.8 (55.51) 553.78.1 × 10−3
WMV (cm3)268485.36 (62.76) 482.7458495.79 (63.78) 493210482.48 (62.32) 476.970.16
WMLV (cm3)2657.69 (14.57) 2.05586.53 (19.46) 0.512078.01 (12.92) 2.884 × 10−4
Hippocampal WMV (cm3)2672.81 (0.35) 2.85582.9 (0.35) 2.952092.79 (0.35) 2.850.05
Hippocampal GMV (cm3)2679.2 (0.98) 9.29589.36 (0.94) 9.42099.16 (0.98) 9.250.17
Hippocampal CSFV (cm3)2681.92 (1.15) 1.57581.58 (0.92) 1.272102.01 (1.19) 1.653.1 × 10−3
  • CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration equation.

  • *Reflects Aorta CP mass score 0.