Table 1

Glucose control during HCL and SAPT + LGS over the 5-day phase in eight subjects with type 1 diabetes

HCLSAPT + LGSP*
Percent time spent at glucose level (mmol/L)
 <3.30.5 (0.0, 0.9); 0.54 ± 0.60.6 (0.0, 1.6); 1.13 ± 1.50.84
 3.3–3.91.0 (0.4, 1.5); 1.15 ± 1.01.4 (0.2, 3.8); 1.98 ± 2.00.89
 4.0–9.967.6 (61.4, 71.5); 67.41 ± 9.858.7 (52.7, 73.9); 60.97 ± 16.40.30
 10.0–14.927.5 (22.0, 32.1); 26.44 ± 9.130.9 (22.2, 38.8); 30.17 ± 12.90.50
 ≥154.5 (2.9, 6.1); 4.46 ± 3.15.0 (0.7, 6.9); 5.75 ± 6.20.34
Sensor glucose (mmol/L)8.2 (6.6, 10.6); 8.8 ± 3.18.9 (6.7, 11.3); 9.2 ± 3.40.47
Duration of observation (h)929926N/A
Hypoglycemic events
 <3.9 mmol/L18260.23§
 <3.3 mmol/L7130.19§
  <2.8 mmol/L190.04§
  • Data shown as median (interquartile range); mean ± SD or n.

  • * P value from a generalized estimate equation of daily data adjusted for the within-person clustering; for 4–9.9 and 10–14.9 mmol/L, percent time in range per day was used; for <3.3, 3.3–3.9, and ≥15 mmol/L, a dichotomous variable per day was analyzed under the binomial distribution.

  • § P value calculated via Poisson regression, with duration of observation as the offset variable.