Table 8.1

Recommendations for statin and combination treatment in people with diabetes

AgeRisk factorsRecommended statin intensity*
<40 years
  • None

  • ASCVD risk factor(s)**

  • ASCVD

  • None

  • Moderate or high

  • High

40–75 years
  • None

  • ASCVD risk factors

  • ASCVD

  • ACS and LDL cholesterol >50 mg/dL (1.3 mmol/L) in patients who cannot tolerate high-dose statins

  • Moderate

  • High

  • High

  • Moderate plus ezetimibe

>75 years
  • None

  • ASCVD risk factors

  • ASCVD

  • ACS and LDL cholesterol >50 mg/dL (1.3 mmol/L) in patients who cannot tolerate high-dose statins

  • Moderate

  • Moderate or high

  • High

  • Moderate plus ezetimibe

  • * In addition to lifestyle therapy.

  • ** ASCVD risk factors include LDL cholesterol ≥100 mg/dL (2.6 mmol/L), high blood pressure, smoking, overweight and obesity, and family history of premature ASCVD.