Table 4

Comparison of risk of renal outcomes of interest using SBP and DBP as linear predictors

Model for SBPHR (per 10 mmHg SBP increase) (95% CI)P valueModel for DBPHR (per 10 mmHg DBP increase) (95% CI)P value
Macroalbuminuria
 Baseline SBP11.00 (0.86–1.17)0.98Baseline DBP11.04 (0.86–1.26)0.69
 Time-updated SBP1.44 (1.28–1.62)<0.001Time-updated DBP1.32 (1.10–1.59)0.003
 Time-updated SBP and DBP in same model1.47 (1.28–1.69)<0.001Time-updated SBP and DBP in same model0.95 (0.77–1.18)0.64
Stage III CKD
 Baseline SBP10.96 (0.78–1.18)0.68Baseline DBP11.23 (0.94–1.61)0.13
 Time-updated SBP1.34 (1.16–1.54)<0.001Time-updated DBP1.41 (1.09–1.82)0.009
 Time-updated SBP and DBP in same model1.32 (1.11–1.57)0.002Time-updated SBP and DBP in same model1.04 (0.76–1.43)0.78
  • All models were adjusted for age, race, sex, education, family history of hypertension, trial arm, and time-dependent covariates, including BMI, use of any antihypertensive medication, albuminuria, eGFR, smoking status, hemoglobin A1c, and use of ACE inhibitors or ARB (all with 1-year lag), unless otherwise specified. HR, hazard ratio.

  • 1Models were adjusted for baseline age, sex, race, education level, family history of hypertension, smoking status, albuminuria, eGFR, trial arm, and BMI.