Table 8.2

Median monthly cost of maximum approved daily dose of noninsulin glucose-lowering agents in the U.S. (48)

ClassCompound(s)Dosage strength/product (if applicable)Median AWP (min, max)Maximum approved daily dose*
Biguanides• Metformin500 mg (IR)$84 ($5, $94)2,000 mg
850 mg (IR)$108 ($5, $108)2,550 mg
1,000 mg (IR)$86 ($4, $87)2,000 mg
500 mg (ER)$90 ($82, $6,672)2,000 mg
750 mg (ER)$72 ($65, $92)1,500 mg
1,000 mg (ER)$1,028 ($1,010, $7,213)2,000 mg
Sulfonylureas (2nd Gen)• Glyburide5 mg$94 ($64, $103)20 mg
6 mg (micronized)$50 ($48, $71)12 mg (micronized)
• Glipizide10 mg (IR)$74 ($67, $97)40 mg (IR)
10 mg (XL)$9720 mg (XL)
• Glimepiride4 mg$74 ($71, $198)8 mg
Meglitinides (glinides)• Repaglinide2 mg$799 ($163, $878)16 mg
• Nateglinide120 mg$156360 mg
TZDs• Pioglitazone45 mg$349 ($348, $349)45 mg
• Rosiglitazone4 mg$3558 mg
α-Glucosidase inhibitors• Acarbose100 mg$104 ($104, 105)300 mg
• Miglitol100 mg$241300 mg
DPP-4 inhibitors• Sitagliptin100 mg$436100 mg
• Saxagliptin5 mg$4365 mg
• Linagliptin5 mg$4285 mg
• Alogliptin25 mg$43625 mg
Bile acid sequestrant• Colesevelam625 mg tabs$6793.75 g
1.875 g suspension$1,3573.75 g
Dopamine-2 agonists• Bromocriptine0.8 mg$7194.8 mg
SGLT2 inhibitors• Canagliflozin300 mg$470300 mg
• Dapagliflozin10 mg$47010 mg
• Empagliflozin25 mg$47025 mg
GLP-1 receptor agonists• Exenatide10 μg pen$72920 μg
• Exenatide (extended-release)2 mg powder for suspension or pen$6922 mg**
• Liraglutide18 mg/3 mL pen$8311.8 mg
• Albiglutide50 mg pen$52750 mg**
• Dulaglutide1.5/0.5 mL pen$6901.5 mg**
Amylin mimetics• Pramlintide120 μg pen$2,124120 μg/injection††
  • ER and XL, extended release; IR, immediate release; TZD, thiazolidinedione.

  • Calculated for 30 day supply (AWP unit price × number of doses required to provide maximum approved daily dose × 30 days); median AWP listed alone when only one product and/or price.

  • * Utilized to calculate median AWP (min, max); generic prices used, if available commercially.

  • ** Administered once weekly.

  • †† AWP calculated based on 120 μg three times daily.